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View Structure Prediction Details

Protein: Poxm-PC
Organism: Drosophila melanogaster
Length: 370 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Poxm-PC.

Description E-value Query
Range
Subject
Range
gi|2696970 - gi|2696970|dbj|BAA24023.1| PAX6 SS [Cynops pyrrhogaster]
280.0 [0..1] [329..13]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPESQCPQY GEVNQLGGVF VNGRPLPNAT RMRIVELARL GIRPCDISRQ LRVSHGCVSK  60
   61 ILARYHETGS ILPGAIGGSK PRVTTPKVVN YIRELKQRDP GIFAWEIRDR LLSEGICDKT 120
  121 NVPSVSSISR ILRNKLGSLG HQHTPGTVMG SGSSSGGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.045757
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [159-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSSNGGQNN GTSASNNINL SNLGNPGGGP HHPHHHHHHQ SAAAAASAHH VHAHAHAHAH  60
   61 LYNSIYQPYS AAAAYSMKTP CGSPSPPQGA GGQGSVPH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [257-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHQLRSVAAA AAAAHWPSSH SVSDILAHHQ AVALRASCQV GVGVGGMGGM GSTVSPLPMT  60
   61 PSPVAGTAGG QPLLDCEGGA GQQSPYNYYM YFQNGGMHHH HHHGGMMAAG ATGL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.12
Match: 1o6dA
Description: Crystal structure of a hypothetical protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.10377840258047 bayes_pls_golite062009
binding 1.70581877784522 bayes_pls_golite062009
protein binding 1.35119799527292 bayes_pls_golite062009
RNA methyltransferase activity 1.08303391887125 bayes_pls_golite062009
catalytic activity 0.759273731741151 bayes_pls_golite062009
transferase activity 0.29748053214444 bayes_pls_golite062009
tRNA methyltransferase activity 0.100848174559199 bayes_pls_golite062009
methyltransferase activity 0.0951797097761462 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.0869374373560942 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle