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View Structure Prediction Details

Protein: TAF4_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 365 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF4_SCHPO.

Description E-value Query
Range
Subject
Range
gi|82996542, gi|... - gi|94405219|ref|XP_983292.1| PREDICTED: similar to Transcription initiation factor TFIID 105 kDa sub...
326.0 [0..20] [343..535]
TAF4B - TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
303.0 [0..19] [343..480]
gi|73961785 - gi|73961785|ref|XP_547629.2| PREDICTED: similar to Transcription initiation factor TFIID 105 kDa sub...
294.0 [0..34] [343..626]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLNNPPSKR FGDDDDIPAN KRPKNEEYPE IPGYLGNRKP SYTQNPNSGP GKLHYASPRP  60
   61 NNVSSSVGVA SGGDRQEADQ LQDALISCGI QLKEEELNLS TSFYDPSSLN TFALTTEDRS 120
  121 RKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.278 0.951 transcription initiation from RNA polymerase II promoter a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #2
Region A:
Residues: [124-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFLNSFVLMQ TVSNIVNLHR LKSMDSDIHA LISMAVRDYL ANLLQKMIVE SHHRTSQLHT  60
   61 DNYKQVDNVR QTLANFAYKE YESEERRRTV LNIRRAEHEA RLAELNSAST NEEGSSRRRK 120
  121 EQSSSAAAKN ISEDAQNRMT NATASIMAGS AL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1h3oA
Description: TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0792897588268993 bayes_pls_golite062009
transcription corepressor activity 0.0736756545988504 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [276-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGGKKYSWM ATDMTPMTPA VGGGFGIRKK DSNSLKPSSR DGVLPLQQEE KGIITIRDAL  60
   61 AVLEMDREGA GRIFGRGAKA MMRAYIRLKD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle