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View Structure Prediction Details

Protein: YLA3_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 475 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLA3_SCHPO.

Description E-value Query
Range
Subject
Range
gi|94390383 - gi|94390383|ref|XP_910122.2| PREDICTED: similar to La ribonucleoprotein domain family, member 1 [Mus...
203.0 [0..97] [471..204]
gi|119625592, gi... - gi|30061569|ref|NP_115615.2| La ribonucleoprotein domain family member 2 isoform 3 [Homo sapiens], g...
199.0 [0..112] [445..2]
gi|109079486 - gi|109079486|ref|XP_001112050.1| PREDICTED: similar to la related protein isoform 1 isoform 3 [Macac...
195.0 [0..25] [471..8]
gi|109488127 - gi|109488127|ref|XP_220446.4| PREDICTED: similar to la related protein isoform 2 [Rattus norvegicus]
191.0 [0..55] [471..144]
gi|76623640 - gi|76623640|ref|XP_582017.2| PREDICTED: similar to la related protein [Bos taurus]
190.0 [0..82] [471..11]
gi|50755001 - gi|50755001|ref|XP_414577.1| PREDICTED: similar to KIAA0731 protein [Gallus gallus]
189.0 [0..63] [471..618]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHKEPSAAE TSTVVHSEED KAFCIGTGAV ISEEREKEVL KNLQNSLTGK TAEENLNDEA  60
   61 NHTSSDKSKS EDYQPSNVNV WALRKEKMIP KKHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [95-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVKQEKRFSK SLQLQDPNVW PSPEIAEKQV EDRKLSDDSQ KPLAPKANGK EKWVTITPNF  60
   61 THTPISNRKS SRSRNDGSRR NGNGRRRGNY SSHGSNKRQT NYSREKDASR SIDSSNPSAE 120
  121 YRDDINNTFG SQTVSSANG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVPQTSEDS SSQAPHHSSS SGHAPSQQGG NKHSYKKSDS QQSFHHKGRN TRKGQRHNNG  60
   61 FYRNIANNIQ GPFPNYPVVV NGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [317-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNPYLCDVQ AFLTSQLEYY FSIENLCKDM FLRKHMDDEG YVPLAFLASF NRIKSFSTDL  60
   61 NLLHAACKAS DIIDVAIDLQ SPMSIKVRRK ETWSPWILPS ESRLKFEMAK YPQINSSSSM 120
  121 SPLASSISNL TISPPFIPSS VDSIIKRDVQ TEVEDKLTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.0
Match: 1ytyA
Description: Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.16805061653531 bayes_pls_golite062009
nucleic acid binding 3.10560219735181 bayes_pls_golite062009
DNA binding 2.97348943886804 bayes_pls_golite062009
structural constituent of ribosome 2.95301685898669 bayes_pls_golite062009
structural molecule activity 2.70976099158766 bayes_pls_golite062009
binding 2.29601364076827 bayes_pls_golite062009
transcription factor activity 2.27922300995509 bayes_pls_golite062009
sequence-specific DNA binding 0.93130370844712 bayes_pls_golite062009
transcription activator activity 0.782193398686323 bayes_pls_golite062009
transcription repressor activity 0.67795138236883 bayes_pls_golite062009
RNA binding 0.345456982950223 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.10854873707001 bayes_pls_golite062009
protein binding 0.057263185425224 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle