YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG6_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	378 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG6_SCHPO.

Description	E-value	Query Range	Subject Range
ERG6_YEAST - Sterol 24-C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG6 PE=1 ... gi\|151946153 - gi\|151946153\|gb\|EDN64384.1\| delta(24)-sterol C-methyltransferase [Saccharomyces cerevisiae YJM789] ERG6 - Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthet...	271.0	[0..1]	[376..1]
ERG6_CANGA - Sterol 24-C-methyltransferase OS=Candida glabrata GN=ERG6 PE=3 SV=1 ERG6_CANGA - Sterol 24-C-methyltransferase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622...	267.0	[0..1]	[376..1]
gi\|62178558 - gi\|62178558\|gb\|AAX73199.1\| C24 sterol methyltransferase [Candida glabrata]	264.0	[0..1]	[376..1]
gi\|46122725, gi\|... - gi\|46122725\|ref\|XP_385916.1\| hypothetical protein FG05740.1 [Gibberella zeae PH-1], gi\|42552972\|gb\|E...	260.0	[0..1]	[375..1]
ERG6_NEUCR - Sterol 24-C-methyltransferase erg-4 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.7... ERG6_NEUCR - Sterol 24-C-methyltransferase OS=Neurospora crassa GN=B24P7.240 PE=3 SV=1	259.0	[0..2]	[376..3]
gi\|86196071, gi\|... - gi\|86196071\|gb\|EAQ70709.1\| hypothetical protein MGCH7_ch7g116 [Magnaporthe grisea 70-15], gi\|3996991...	258.0	[0..7]	[376..11]
gi\|114195434, gi... - gi\|115387689\|ref\|XP_001211350.1\| sterol 24-C-methyltransferase [Aspergillus terreus NIH2624], gi\|114...	257.0	[0..1]	[375..1]
gi\|159122217 - gi\|159122217\|gb\|EDP47339.1\| sterol 24-c-methyltransferase, putative [Aspergillus fumigatus A1163] gi\|66844173, gi\|... - gi\|70982043\|ref\|XP_746550.1\| sterol 24-c-methyltransferase [Aspergillus fumigatus Af293], gi\|6684417...	256.0	[0..1]	[375..1]

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Predicted Domain #1

Region A:
Residues: [1-79]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTALLPPN TDQVLSRRLH GKAAEKKTGL AAIASKDVDE QSRKLQEYFE FWDRNHENES  60
   61 EEDRARRIDG YKSVVNSYY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.154902
Match:	2as0A
Description:	Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [80-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLATDLYEYG WSQSFHFSRF YKGEAFAQSI ARHEHYLAYR MGIKPGSRVL DVGCGVGGPA  60
   61 REITEFTGCN LVGLNNNDYQ ISRCNNYAVK RNLDKKQVFV KGDFMHMPFE DNTFDYVYAI 120
  121 EATVHAPSLE GVYGEIFRVL KPGGVFGVYE WVMSDDYDSS IPKHREIAYN IEVGDGIPQM 180
  181 VRKCDAVEAI KKVGFNLLEE DDLTDHDNPD LPWYYPLTGD ITKCQNIWDV FTVFRTSRLG 240
  241 KLVTRYSVQF LEKIGVAAKG TSKVGDTLAI AQKGLIEGGE THLFTPMFLM IAKKPETDA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.522879
Match:	1kp9A
Description:	CmaA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
binding	0.422181371325275	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.181420092548185	bayes_pls_golite062009
DNA binding	0.00720144044916005	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: