YRC Public Data Repository - Protein Structure Prediction

Protein:	FAHD1_MOUSE
Organism:	Mus musculus
Length:	227 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FAHD1_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|76795471, gi\|... - gi\|76795471\|ref\|ZP_00777844.1\| 5-carboxymethyl-2-hydroxymuconate delta-isomerase [Thermoanaerobacter... gi\|241885014, gi... - gi\|241902552\|ref\|ZP_04787285.1\| 5-carboxymethyl-2-hydroxymuconate Delta-isomerase [Thermoanaerobacte... gi\|166853110, gi... - gi\|167038870\|ref\|YP_001661855.1\| 5-carboxymethyl-2-hydroxymuconate Delta-isomerase [Thermoanaerobact... gi\|242256983, gi... - gi\|242256983\|ref\|ZP_04801862.1\| 5-carboxymethyl-2-hydroxymuconate Delta-isomerase [Thermoanaerobacte...	276.0	[0..4]	[223..31]
gi\|254478445, gi... - gi\|254478445\|ref\|ZP_05091822.1\| fumarylacetoacetate hydrolase family protein, putative [Carboxydibra... gi\|20806781 - gi\|20806781\|ref\|NP_621952.1\| 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase... gi\|20515242, gi\|... - gi\|20806781\|ref\|NP_621952.1\| 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase...	270.0	[0..2]	[223..29]
FAHD1_MOUSE - Acylpyruvase FAHD1, mitochondrial OS=Mus musculus GN=Fahd1 PE=1 SV=1	270.0	[0..1]	[227..1]
FAHD2_XENLA - Fumarylacetoacetate hydrolase domain-containing protein 2 OS=Xenopus laevis GN=fahd2 PE=2 SV=1	268.0	[0..3]	[223..94]
gi\|77996639, gi\|... - gi\|78044524\|ref\|YP_360632.1\| fumarylacetoacetate hydrolase family protein [Carboxydothermus hydrogen...	267.0	[0..5]	[223..40]
gi\|73980261 - gi\|73980261\|ref\|XP_532952.2\| PREDICTED: similar to fumarylacetoacetate hydrolase domain containing 2...	265.0	[0..5]	[223..90]
gi\|110620076, gi... - gi\|147921505\|ref\|YP_684680.1\| fumarylacetoacetate hydrolase family protein [uncultured methanogenic ...	264.0	[0..5]	[223..32]
gi\|47086199, gi\|... - gi\|47086199\|ref\|NP_998083.1\| fumarylacetoacetate hydrolase domain containing 2A [Danio rerio], gi\|45...	264.0	[0..5]	[223..66]
gi\|109103869 - gi\|109103869\|ref\|XP_001095387.1\| PREDICTED: similar to fumarylacetoacetate hydrolase domain containi...	264.0	[0..5]	[223..36]
gi\|20906262, gi\|... - gi\|21227849\|ref\|NP_633771.1\| fumarylacetoacetate hydrolase family protein [Methanosarcina mazei Go1]...	264.0	[0..3]	[223..30]

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Predicted Domain #1

Region A:
Residues: [1-227]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQSCTMAST KPLSRFWEWG KNIVCVGRNY ADHVKEMRST VLSEPVLFLK PSTAYAPEGS  60
   61 PVLMPAYCRN LHHEVELGVL LGKRGEAIPE AAAMDYVAGY ALCLDMTARD VQEECKKKGL 120
  121 PWTLAKSFTS SCPVSAFVPK EKIPDPHALR LWLKVNGELR QEGKTSSMIF SIPYIISYVS 180
  181 KIITLEEGDL ILTGTPKGVG PIKENDEIEA GIDGVVSMRF KVKRSEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.0
Match:	1sawA
Description:	X-ray structure of homo sapiens protein FLJ36880
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity, acting on acid carbon-carbon bonds	3.47506644461251	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	3.3661586952187	bayes_pls_golite062009
catalytic activity	1.43840931606572	bayes_pls_golite062009
binding	0.917289226788792	bayes_pls_golite062009
protein binding	0.334167038998597	bayes_pls_golite062009
hydrolase activity	0.145057589038159	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: