YRC Public Data Repository - Protein Structure Prediction

Protein:	PHS_MOUSE
Organism:	Mus musculus
Length:	104 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHS_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|47221757 - gi\|47221757\|emb\|CAG08811.1\| unnamed protein product [Tetraodon nigroviridis]	159.0	[0..1]	[103..35]
gi\|56553689, gi\|... - gi\|56553690\|pdb\|1RU0\|B Chain B, Crystal Structure Of Dcoh2, A Paralog Of Dcoh, The Dimerization Cofa...	159.0	[0..1]	[103..3]
gi\|52354802, gi\|... - gi\|52354802\|gb\|AAH82836.1\| LOC397951 protein [Xenopus laevis], gi\|147898540\|ref\|NP_001081611.1\| XDCo...	157.0	[0..1]	[104..1]
gi\|73587149 - gi\|73587149\|gb\|AAI03435.1\| PCBD1 protein [Bos taurus]	157.0	[0..1]	[104..40]
gi\|57033048, gi\|... - gi\|57033048\|gb\|AAH88970.1\| LOC496367 protein [Xenopus laevis], gi\|148237203\|ref\|NP_001088985.1\| hypo... gi\|52139103, gi\|... - gi\|89271979\|emb\|CAJ82265.1\| 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte...	156.0	[0..1]	[104..1]
CE18240 - WBGene00020397 locus:pcbd-1 status:Partially_confirmed	156.0	[0..4]	[101..80]
gi\|73971304 - gi\|73971304\|ref\|XP_852425.1\| PREDICTED: similar to dimerization cofactor of hepatocyte nuclear facto...	155.0	[0..2]	[103..43]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGKAHRLSA EERDQLLPNL RAVGWNEVEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL  60
   61 DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.045757
Match:	1dchA
Description:	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
4-alpha-hydroxytetrahydrobiopterin dehydratase activity	6.27157822952381	bayes_pls_golite062009
transcription regulator activity	2.43253022834875	bayes_pls_golite062009
phenylalanine 4-monooxygenase activity	2.07153680701772	bayes_pls_golite062009
binding	1.91757396487631	bayes_pls_golite062009
transcription activator activity	1.76965686339133	bayes_pls_golite062009
protein binding	1.5922433129317	bayes_pls_golite062009
catalytic activity	1.39967796334655	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	1.1107181321593	bayes_pls_golite062009
carbon-oxygen lyase activity	0.738746392707103	bayes_pls_golite062009
hydro-lyase activity	0.699903508958642	bayes_pls_golite062009
lyase activity	0.685050647082958	bayes_pls_golite062009
transcription factor binding	0.303837517417996	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: