YRC Public Data Repository - Protein Structure Prediction

Protein:	HEN2_MOUSE
Organism:	Mus musculus
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEN2_MOUSE.

Description	E-value	Query Range	Subject Range
HEN2_MOUSE - Helix-loop-helix protein 2 OS=Mus musculus GN=Nhlh2 PE=2 SV=1 gi\|251798 - gi\|251798\|gb\|AAB22580.1\| basic domain helix-loop-helix gene [Mus sp.]	118.0	[0..1]	[135..1]
gi\|157824067, gi... - gi\|27660130\|ref\|XP_227524.1\| PREDICTED: similar to nescient helix loop helix 2 [Rattus norvegicus], ...	117.0	[0..1]	[135..1]
gi\|114558664, gi... - gi\|114558668\|ref\|XP_001148366.1\| PREDICTED: similar to helix-loop-helix protein isoform 1 [Pan trogl... NHLH2 - nescient helix loop helix 2 gi\|109014532, gi... - gi\|109014535\|ref\|XP_001112029.1\| PREDICTED: similar to Helix-loop-helix protein 2 (HEN2) (Nescient h...	115.0	[0..1]	[135..1]
gi\|73981146 - gi\|73981146\|ref\|XP_540253.2\| PREDICTED: similar to nescient helix loop helix 2 [Canis familiaris]	110.0	[0..1]	[135..203]
gi\|76612998, gi\|... - gi\|76613000\|ref\|XP_604054.2\| PREDICTED: similar to Helix-loop-helix protein 2 (HEN2) (Nescient helix...	110.0	[0..1]	[135..1]
gi\|7804955 - gi\|7804955\|gb\|AAF70195.1\|AF253470_1 myogenic regulatory factor myf5 [Danio rerio]	102.0	[0..9]	[134..1]
gi\|66735448 - gi\|66735448\|gb\|AAY53906.1\| bHLH muscle transcription factor MRF4 [Sternopygus macrurus]	102.0	[0..16]	[133..34]
gi\|74136157, gi\|... - gi\|74136157\|ref\|NP_001027941.1\| myoblast determination protein [Takifugu rubripes], gi\|40074258\|gb\|A...	101.0	[0..38]	[134..70]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLSPDQAAD SDHPSSTHSD PESLGGADTK VLGSVSDLEP VEEADGDGKG GSRAALYPHP  60
   61 QQLSREEKRR RRRATAKYRS AHATRERIRV EAFNLAFAEL RKLLPTLPPD KKLSKIEILR 120
  121 LAICYISYLN HVLDV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.09691
Match:	1mdyA
Description:	Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.48015842216783	bayes_pls_golite062009
DNA binding	1.68227054158471	bayes_pls_golite062009
nucleic acid binding	1.49015904409851	bayes_pls_golite062009
transcription factor activity	1.44849583176285	bayes_pls_golite062009
transcription regulator activity	1.44430913433076	bayes_pls_golite062009
protein binding	1.36665585692075	bayes_pls_golite062009
sequence-specific DNA binding	0.23534942710392	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.185301839243976	bayes_pls_golite062009
transcription factor binding	0.136765378218539	bayes_pls_golite062009
transcription activator activity	0.104368037377197	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: