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View Structure Prediction Details

Protein: CAP2
Organism: Homo sapiens
Length: 477 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAP2.

Description E-value Query
Range
Subject
Range
gi|55729652 - gi|55729652|emb|CAH91555.1| hypothetical protein [Pongo abelii]
gi|197098662 - gi|197098662|ref|NP_001125913.1| CAP, adenylate cyclase-associated protein, 2 [Pongo abelii]
0.0 [1..477] [1..477]
gi|109069713 - gi|109069713|ref|XP_001095462.1| PREDICTED: similar to adenylyl cyclase-associated protein 2 isoform...
0.0 [1..477] [1..477]
gi|60653725 - gi|60653725|gb|AAX29556.1| adenylate cyclase-associated protein 2 [synthetic construct]
0.0 [1..477] [1..477]
gi|114605601, gi... - gi|114605601|ref|XP_001170453.1| PREDICTED: adenylyl cyclase-associated protein 2 isoform 6 [Pan tro...
0.0 [1..477] [1..477]
gi|55957701, gi|... - gi|56203267|emb|CAC26824.2| CAP, adenylate cyclase-associated protein, 2 (yeast) [Homo sapiens], gi|...
0.0 [4..477] [1..474]
CAP2_MOUSE - Adenylyl cyclase-associated protein 2 OS=Mus musculus GN=Cap2 PE=1 SV=1
0.0 [1..477] [1..476]
gi|74003936 - gi|74003936|ref|XP_535897.2| PREDICTED: similar to adenylyl cyclase-associated protein 2 isoform 1 [...
0.0 [1..476] [1..476]

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Predicted Domain #1
Region A:
Residues: [1-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD KLMDSMVAEF  60
   61 LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE NDVAALLKPI SEKIQEIQTF 120
  121 RERNRGSNMF NHLSAVSESI PALGWIAVSP KPGPYVKEMN DAATFYTNRV LKDYKHSDLR 180
  181 HVDWVKSYLN IWSELQAYIK EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP 240
  241 PGPPPLFENE GKKEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.69897
Match: 1tjfA
Description: The crystal structure of the N-terminal domain of CAP indicates variable oligomerisation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 5.81884714997094 bayes_pls_golite062009
cytoskeletal protein binding 4.39652693178112 bayes_pls_golite062009
adenylate cyclase binding 2.08284870927262 bayes_pls_golite062009
binding 1.8340549733034 bayes_pls_golite062009
enzyme binding 1.53072876683435 bayes_pls_golite062009
protein binding 0.871734119777931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [256-320]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSPSRSALFA QLNQGEAITK GLRHVTDDQK TYKNPSLRAQ GGQTQSPTKS HTPSPTSPKS  60
   61 YPSQK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [321-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAPVLELEGK KWRVEYQEDR NDLVISETEL KQVAYIFKCE KSTIQIKGKV NSIIIDNCKK  60
   61 LGLVFDNVVG IVEVINSQDI QIQVMGRVPT ISINKTEGCH IYLSEDALDC EIVSAKSSEM 120
  121 NILIPQDGDY REFPIPEQFK TAWDGSKLIT EPAEIMA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.522879
Match: 1k8fA
Description: C-terminal domain of adenylylcyclase associated protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 4.94933252861141 bayes_pls_golite062009
cytoskeletal protein binding 4.21664682046338 bayes_pls_golite062009
actin monomer binding 2.04365563273836 bayes_pls_golite062009
binding 1.57578562719958 bayes_pls_golite062009
adenylate cyclase binding 1.13353932343086 bayes_pls_golite062009
enzyme binding 0.705135358375 bayes_pls_golite062009
protein binding 0.651719649953198 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle