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View Structure Prediction Details

Protein: gi|119592811, gi...
Organism: Homo sapiens
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119592811, gi....

Description E-value Query
Range
Subject
Range
gi|109126149 - gi|109126149|ref|XP_001089860.1| PREDICTED: epsin 1 isoform 2 [Macaca mulatta]
5.0E-57 [1..576] [1..576]
gi|84579843, gi|... - gi|84579843|ref|NP_001033759.1| epsin 1 [Bos taurus], gi|83759106|gb|AAI10281.1| Epsin 1 [Bos taurus...
1.0E-56 [1..576] [1..576]
gi|49903949, gi|... - gi|50300479|ref|NP_001002022.1| enthoprotin [Rattus norvegicus], gi|49903949|gb|AAH76397.1| Enthopro...
8.0E-56 [3..412] [7..458]
gi|119615012, gi... - gi|50417637|gb|AAH77722.1| EPN3 protein [Homo sapiens], gi|30411009|gb|AAH51365.1| EPN3 protein [Hom...
2.0E-55 [1..211] [1..208]
gi|114679169, gi... - gi|114679173|ref|XP_001137339.1| PREDICTED: hypothetical protein isoform 7 [Pan troglodytes], gi|114...
6.0E-55 [1..576] [1..584]
EPN1_MOUSE - Epsin-1 OS=Mus musculus GN=Epn1 PE=1 SV=3
2.0E-53 [1..576] [1..575]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI  60
   61 WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 120
  121 VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.39794
Match: 1h0aA
Description: Epsin 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 2.72990983638976 bayes_pls_golite062009
binding 2.13445840178249 bayes_pls_golite062009
protein binding 1.97365365208963 bayes_pls_golite062009
phospholipid binding 1.38798066582556 bayes_pls_golite062009
phosphoinositide binding 1.26458267960741 bayes_pls_golite062009
lipid binding 0.4499495998145 bayes_pls_golite062009
protein domain specific binding 0.14699617064037 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [158-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATASSAAVGS GPPPEAEQAW PQSSGEEELQ LQLALAMSKE EADQPPSCGP EDDAQLQLAL  60
   61 SLSREEHDKE ERIRRGDDL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [237-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLQMAIEESK RETGGKEESS LMDLADVFTA PAPAPTTDPW GGPAPMAAAV PTAAPTSDPW  60
   61 GGPPVPPAAD PWGGPAPTPA SGDPWRPAAP AGPSVDPWGG TPAPAAGEGP TPDPWGSSDG 120
  121 GVPVSGPSAS DPWTPAPAFS DPWGGSPAKP STNGTTAAGG FDTEPDEFSD FDRLRTALPT 180
  181 SGSSAGELEL LAGEVPARSP GAFDMSGVRG SLAEAVGSPP PAATPTPTPP TRKTPESFLG 240
  241 PNAALVDLDS LVSRPGPTPP GAKASNPFLP GGGPA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [512-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGPSVTNPFQ PAPPATLTLN QLRLSPVPPV PGAPPTYISP LGGGPGLPPM MPPGPPAPNT  60
   61 NPFLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle