YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF4
Organism:	Homo sapiens
Length:	206 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF4.

Description	E-value	Query Range	Subject Range
gi\|109105124 - gi\|109105124\|ref\|XP_001100747.1\| PREDICTED: fibroblast growth factor 4 (heparin secretory transformi... gi\|114639012 - gi\|114639012\|ref\|XP_001173970.1\| PREDICTED: fibroblast growth factor 4 [Pan troglodytes]	7.0E-56	[1..206]	[1..206]
gi\|73983565 - gi\|73983565\|ref\|XP_540801.2\| PREDICTED: similar to Fibroblast growth factor-4 precursor (FGF-4) (Hep...	4.0E-55	[22..206]	[22..206]
gi\|2118526 - gi\|2118526\|pir\|\|JC4268 fibroblast growth factor 4 - bovine	9.0E-52	[27..206]	[26..206]
FGF4B_XENLA - Fibroblast growth factor 4B OS=Xenopus laevis GN=fgf4-b PE=2 SV=1	4.0E-50	[5..206]	[1..192]
gi\|84798489, gi\|... - gi\|89191828\|ref\|NP_001001398.2\| fibroblast growth factor 6a [Danio rerio], gi\|84798489\|gb\|ABC67200.1...	2.0E-49	[2..206]	[15..205]
gi\|114642913 - gi\|114642913\|ref\|XP_001157123.1\| PREDICTED: fibroblast growth factor 6 [Pan troglodytes]	1.0E-48	[5..206]	[20..208]
gi\|3980190 - gi\|3980190\|emb\|CAA76422.1\| fibroblast growth factor 6-related protein [Oncorhynchus mykiss]	1.0E-48	[5..206]	[19..206]

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Predicted Domain #1

Region A:
Residues: [1-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV  60
   61 AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 120
  121 VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 180
  181 LSKNGKTKKG NRVSPTMKVT HFLPRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.522879
Match:	1ijtA
Description:	Fibroblast growth factor 4 (FGF4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fibroblast growth factor receptor binding	5.68976822724664	bayes_pls_golite062009
growth factor activity	5.6790632853895	bayes_pls_golite062009
receptor binding	4.8109037277027	bayes_pls_golite062009
cytokine activity	3.72907359340826	bayes_pls_golite062009
protein binding	2.99442649109752	bayes_pls_golite062009
binding	2.90110516688922	bayes_pls_golite062009
glycosaminoglycan binding	2.49177421879896	bayes_pls_golite062009
heparin binding	2.1616134585534	bayes_pls_golite062009
polysaccharide binding	1.81686028727894	bayes_pls_golite062009
signal transducer activity	1.24692031673405	bayes_pls_golite062009
molecular transducer activity	1.24692031673405	bayes_pls_golite062009
interleukin-1 receptor binding	0.8084616632765	bayes_pls_golite062009
pattern binding	0.323275442862789	bayes_pls_golite062009
nerve growth factor receptor binding	0.308245352535379	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: