YRC Public Data Repository - Protein Structure Prediction

Protein:	DIABLO
Organism:	Homo sapiens
Length:	239 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DIABLO.

Description	E-value	Query Range	Subject Range
gi\|109099086 - gi\|109099086\|ref\|XP_001097400.1\| PREDICTED: diablo homolog (Drosophila) isoform 5 [Macaca mulatta]	0.0	[1..239]	[1..239]
gi\|114647540 - gi\|114647540\|ref\|XP_001150587.1\| PREDICTED: similar to Smac [Pan troglodytes]	0.0	[17..239]	[146..368]
gi\|10437144 - gi\|10437144\|dbj\|BAB14994.1\| unnamed protein product [Homo sapiens]	0.0	[1..239]	[1..239]
DBLOH_PONPY - Diablo homolog, mitochondrial precursor - Pongo pygmaeus (Orangutan) DBLOH_PONAB - Diablo homolog, mitochondrial OS=Pongo abelii GN=DIABLO PE=2 SV=1	0.0	[1..239]	[1..239]
DBLOH_MOUSE, DBO... - (Q9JIQ3) Diablo homolog, mitochondrial precursor (Second mitochondria-derived activator of caspase) ...	0.0	[1..239]	[1..237]
gi\|119331166, gi... - gi\|73994503\|ref\|XP_849730.1\| PREDICTED: similar to Diablo homolog, mitochondrial precursor (Second m...	0.0	[1..239]	[1..237]
gi\|84708706, gi\|... - gi\|84708706\|gb\|AAI11128.1\| Diablo homolog (Drosophila) [Bos taurus], gi\|76638944\|ref\|XP_872126.1\| PR...	0.0	[1..239]	[1..238]

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Predicted Domain #1

Region A:
Residues: [1-239]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALKSWLSR SVTSFFRYRQ CLCVPVVANF KKRCFSELIR PWHKTVTIGF GVTLCAVPIA  60
   61 QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL 120
  121 LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS 180
  181 ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.154902
Match:	1fewA
Description:	Smac/diablo
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	1.94841008133032	bayes_pls_golite062009
binding	1.81583144634226	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: