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View Structure Prediction Details

Protein: MPI
Organism: Homo sapiens
Length: 423 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPI.

Description E-value Query
Range
Subject
Range
gi|114658120 - gi|114658120|ref|XP_001140578.1| PREDICTED: mannose-6- phosphate isomerase isoform 11 [Pan troglodyt...
0.0 [1..423] [1..423]
MPI_MACFA - Mannose-6-phosphate isomerase OS=Macaca fascicularis GN=MPI PE=2 SV=3
0.0 [1..423] [1..423]
MPI_BOVIN - Mannose-6-phosphate isomerase OS=Bos taurus GN=MPI PE=2 SV=3
0.0 [1..423] [1..423]
gi|14290579 - gi|14290579|gb|AAH09068.1| Mannose phosphate isomerase [Mus musculus]
0.0 [1..423] [1..423]
MPI_RAT - Mannose-6-phosphate isomerase OS=Rattus norvegicus GN=Mpi PE=2 SV=1
0.0 [1..423] [1..423]
gi|74000763 - gi|74000763|ref|XP_535543.2| PREDICTED: similar to mannose-6- phosphate isomerase isoform 1 [Canis f...
0.0 [1..423] [1..421]

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Predicted Domain #1
Region A:
Residues: [1-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPRVFPLS CAVQQYAWGK MGSNSEVARL LASSDPLAQI AEDKPYAELW MGTHPRGDAK  60
   61 ILDNRISQKT LSQWIAENQD SLGSKVKDTF NGNLPFLFKV LSVETPLSIQ AHPNKELAEK 120
  121 LHLQAPQHYP DANHKPEMAI ALTPFQGLCG FRPVEEIVTF LKKVPEFQFL IGDEAATHLK 180
  181 QTMSHDSQAV ASSLQSCFSH LMKSEKKVVV EQLNLLVKRI SQQAAAGNNM EDIFGELLLQ 240
  241 LHQQYPGDIG CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP 300
  301 KFIDVPTLCE MLSYTPSSSK DRLFLPTRSQ EDPYLSIYDP PVPDFTIMKT EVPGSVTEYK 360
  361 VLALDSASIL LMVQGTVIAS TPTTQTPIPL QRGGVLFIGA NESVSLKLTE PKDLLIFRAC 420
  421 CLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1pmiA
Description: HUMAN RANTES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.86690435826277 bayes_pls_golite062009
nucleic acid binding 1.64913898350018 bayes_pls_golite062009
DNA binding 1.57178406956273 bayes_pls_golite062009
binding 1.54596514444405 bayes_pls_golite062009
transcription factor activity 0.937392765385803 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.8581504516071 bayes_pls_golite062009
catalytic activity 0.401988496917198 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0.353173877157675 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0.348782780143283 bayes_pls_golite062009
protein binding 0.110960530780648 bayes_pls_golite062009

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