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View Structure Prediction Details

Protein: EREG
Organism: Homo sapiens
Length: 169 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EREG.

Description E-value Query
Range
Subject
Range
gi|60825082 - gi|60825082|gb|AAX36706.1| epiregulin [synthetic construct]
2.0E-37 [1..169] [1..169]
gi|114594256 - gi|114594256|ref|XP_001155238.1| PREDICTED: epiregulin [Pan troglodytes]
sp|O14944-1|EREG... - Proepiregulin OS=Homo sapiens GN=EREG PE=1 SV=1 VAR_033827, Proepiregulin OS=Homo sapiens GN=EREG PE...
7.0E-37 [1..169] [1..169]
EREG_RAT - Proepiregulin OS=Rattus norvegicus GN=Ereg PE=1 SV=1
1.0E-36 [7..169] [1..162]
EREG_MOUSE - Proepiregulin OS=Mus musculus GN=Ereg PE=1 SV=1
1.0E-36 [7..169] [1..162]
gi|61833031 - gi|61833031|ref|XP_596732.1| PREDICTED: similar to epiregulin, partial [Bos taurus]
1.0E-32 [24..169] [1..146]
gi|7706717, gi|6... - ref|NP_057331.1| interphotoreceptor matrix proteoglycan 2 [Homo sapiens], gi|6318680|gb|AAF06999.1|...
2.0E-30 [6..167] [982..1147]
CCDS3564.1_1 - null
gi|109074492 - gi|109074492|ref|XP_001102069.1| PREDICTED: similar to epiregulin precursor [Macaca mulatta]
2.0E-30 [1..169] [1..169]

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Predicted Domain #1
Region A:
Residues: [1-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAGRRMEML CAGRVPALLL CLGFHLLQAV LSTTVIPSCI PGESSDNCTA LVQTEDNPRV  60
   61 AQVSITKCSS DMNGYCLHGQ CIYLVDMSQN YCRCEVGYTG VRCEHFFLTV HQPLSKEYVA 120
  121 LTVILIILFL ITVVGSTYYF CRWYRNRKSK EPKKEYERVT SGDPELPQV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1p9jA
Description: Solution structure and dynamics of the EGF/TGF-alpha chimera T1E
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ErbB-2 class receptor binding 5.8995982132645 bayes_pls_golite062009
ErbB-3 class receptor binding 5.34788747664513 bayes_pls_golite062009
epidermal growth factor receptor binding 4.96984057897789 bayes_pls_golite062009
growth factor activity 4.72461268561406 bayes_pls_golite062009
receptor binding 4.33045214660893 bayes_pls_golite062009
glycosaminoglycan binding 3.49243532917035 bayes_pls_golite062009
heparin binding 3.18889412817519 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
polysaccharide binding 2.79319890241656 bayes_pls_golite062009
binding 2.33940742543305 bayes_pls_golite062009
molecular transducer activity 1.66401431847753 bayes_pls_golite062009
signal transducer activity 1.66401431847753 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
protein kinase activity 1.1805362342952 bayes_pls_golite062009
transcription factor binding 1.01285047489209 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.938291184527564 bayes_pls_golite062009
transcription cofactor activity 0.935213701014088 bayes_pls_golite062009
kinase activity 0.857148885514521 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009
transcription regulator activity 0.326255385249624 bayes_pls_golite062009

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