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View Structure Prediction Details

Protein: PPAT
Organism: Homo sapiens
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPAT.

Description E-value Query
Range
Subject
Range
gi|73975309 - gi|73975309|ref|XP_854170.1| PREDICTED: similar to phosphoribosyl pyrophosphate amidotransferase pro...
0.0 [1..517] [1..517]
gi|62897077 - gi|62897077|dbj|BAD96479.1| phosphoribosyl pyrophosphate amidotransferase proprotein variant [Homo s...
0.0 [1..517] [1..517]
gi|114594661 - gi|114594661|ref|XP_001140991.1| PREDICTED: phosphoribosyl pyrophosphate amidotransferase isoform 2 ...
0.0 [1..517] [1..517]
gi|109074759 - gi|109074759|ref|XP_001085606.1| PREDICTED: similar to phosphoribosyl pyrophosphate amidotransferase...
0.0 [1..517] [1..517]
PUR1_RAT - Amidophosphoribosyltransferase OS=Rattus norvegicus GN=Ppat PE=1 SV=1
0.0 [1..517] [1..517]
gi|82897716, gi|... - gi|94376406|ref|XP_979032.1| PREDICTED: similar to Amidophosphoribosyltransferase precursor (Glutami...
0.0 [1..517] [1..517]

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Predicted Domain #1
Region A:
Residues: [1-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELEELGIRE ECGVFGCIAS GEWPTQLDVP HVITLGLVGL QHRGQESAGI VTSDGSSVPT  60
   61 FKSHKGMGLV NHVFTEDNLK KLYVSNLGIG HTRYATTGKC ELENCQPFVV ETLHGKIAVA 120
  121 HNGELVNAAR LRKKLLRHGI GLSTSSDSEM ITQLLAYTPP QEQDDTPDWV ARIKNLMKEA 180
  181 PTAYSLLIMH RDVIYAVRDP YGNRPLCIGR LIPVSDINDK EKKTSETEGW VVSSESCSFL 240
  241 SIGARYYREV LPGEIVEISR HNVQTLDIIS RSEGNPVAFC IFEYVYFARP DSMFEDQMVY 300
  301 TVRYRCGQQL AIEAPVDADL VSTVPESATP AALAYAGKCG LPYVEVLCKN RYVGRTFIQP 360
  361 NMRLRQLGVA KKFGVLSDNF KGKRIVLVDD SIVRGNTISP IIKLLKESGA KEVHIRVASP 420
  421 PIKYPCFMGI NIPTKEELIA NKPEFDHLAE YLGANSVVYL SVEGLVSSVQ EGIKFKKQKE 480
  481 KKHDIMIQEN GNGLECFEKS GHCTACLTGK YPVELEW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 88.0
Match: 1ao0A
Description: Glutamine PRPP amidotransferase, C-terminal domain; Glutamine PRPP amidotransferase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uracil phosphoribosyltransferase activity 2.36237864658341 bayes_pls_golite062009
ribose phosphate diphosphokinase activity 1.51875493459374 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009
adenine phosphoribosyltransferase activity 0.985266832225609 bayes_pls_golite062009
diphosphotransferase activity 0.749909396904601 bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity 0.625087274084001 bayes_pls_golite062009
nucleic acid binding 0.283725923623827 bayes_pls_golite062009
ligase activity 0.204093345072151 bayes_pls_golite062009
orotate phosphoribosyltransferase activity 0.148898393751978 bayes_pls_golite062009
endopeptidase activity 0.0940838340168359 bayes_pls_golite062009
peptidase activity 0.0898497842822991 bayes_pls_golite062009
transcription regulator activity 0.057753538747651 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.012663147802059 bayes_pls_golite062009
protein binding 0.00621436730716318 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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