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View Structure Prediction Details

Protein: gi|23943854, gi|...
Organism: Homo sapiens
Length: 388 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|23943854, gi|....

Description E-value Query
Range
Subject
Range
PEPA_CANLF - Pepsin A OS=Canis lupus familiaris GN=PGA PE=2 SV=1
0.0 [1..388] [1..386]
gi|114637858 - gi|114637858|ref|XP_001145137.1| PREDICTED: pepsinogen 5, group I (pepsinogen A) isoform 4 [Pan trog...
0.0 [1..388] [1..388]
gi|157170280 - gi|157170280|gb|AAI52845.1| Pepsinogen 4, group I (pepsinogen A) [synthetic construct]
,HsxXG003545,F12... - null
PGA3, PGA5, PGA4 - pepsinogen 5, group I (pepsinogen A), pepsinogen 4, group I (pepsinogen A), pepsinogen 3, group I (p...
0.0 [1..388] [1..388]
gi|38069, gi|105009 - gi|38069|emb|CAA42427.1| prepropepsin a; prepropepsinogen A-2/3 [Macaca fuscata], pir||S19684 pepsin...
PEPA2_MACFU - Pepsin A-2/A-3 OS=Macaca fuscata fuscata PE=1 SV=1
0.0 [1..388] [1..388]

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Predicted Domain #1
Region A:
Residues: [1-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP  60
   61 TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP 120
  121 EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD 180
  181 GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DKSGSVVIFG GIDSSYYTGS 240
  241 LNWVPVTVEG YWQITVDSIT MNGETIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS 300
  301 ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNVPTESGEL 360
  361 WILGDVFIRQ YFTVFDRANN QVGLAPVA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 106.0
Match: 2psgA
Description: REFINED STRUCTURE OF PORCINE PEPSINOGEN AT 1.8 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.9145950161796 bayes_pls_golite062009
aspartic-type peptidase activity 7.9145950161796 bayes_pls_golite062009
peptidase activity 5.78181196721293 bayes_pls_golite062009
endopeptidase activity 5.4888481808613 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.39972232367526 bayes_pls_golite062009
hydrolase activity 4.34796304893506 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
protein binding 1.24436201877985 bayes_pls_golite062009
binding 1.10054369202721 bayes_pls_golite062009
receptor binding 1.06854757360057 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle