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View Structure Prediction Details

Protein: gi|6013006, gi|3...
Organism: Homo sapiens
Length: 491 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|6013006, gi|3....

Description E-value Query
Range
Subject
Range
gi|114613805 - gi|114613805|ref|XP_519132.2| PREDICTED: RAB guanine nucleotide exchange factor (GEF) 1 [Pan troglod...
0.0 [1..491] [339..830]
gi|61369698, gi|... - gi|61369703|gb|AAX43377.1| RAB guanine nucleotide exchange factor 1 [synthetic construct], gi|613696...
0.0 [1..491] [1..491]
gi|62898219 - gi|62898219|dbj|BAD97049.1| RAB guanine nucleotide exchange factor (GEF) 1 variant [Homo sapiens]
0.0 [1..491] [1..491]
RABX5_MOUSE - Rab5 GDP/GTP exchange factor OS=Mus musculus GN=Rabgef1 PE=1 SV=1
0.0 [1..491] [1..491]
gi|83638523 - gi|83638523|gb|AAI09492.1| RABGEF1 protein [Bos taurus]
0.0 [1..491] [1..491]
gi|149063142, gi... - gi|149063142|gb|EDM13465.1| RAB guanine nucleotide exchange factor (GEF) 1 (predicted), isoform CRA_...
0.0 [1..491] [1..491]
gi|73957601 - gi|73957601|ref|XP_856158.1| PREDICTED: similar to Rab5 GDP/GTP exchange factor (Rabex-5) isoform 3 ...
0.0 [1..491] [1..491]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKSERRGI HVDQSDLLCK KGCGYYGNPA WQGFCSKCWR EEYHKARQKQ IQEDWELAER  60
   61 LQREEEEAFA SSQSSQGAQS LTFSKFEEKK TNEKTRKVT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.30103
Match: 2c7mA
Description: human Rabex-5 residues 1-74 in complex with Ubiquitin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [100-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVKKFFSASS RVGSKKEIQE AKAPSPSINR QTSIETDRVS KEFIEFLKTF HKTGQEIYKQ  60
   61 TKLFLEGMHY KRDLSIEEQS ECAQDFYHNV AERMQTRGKV PPERVEKIMD QIEKYIMTRL 120
  121 YKYVFCPETT DDEKKDLAIQ KRIRALRWVT PQMLCVPVNE DIPEVSDMVV KAITDIIEMD 180
  181 SKRVPRDKLA CITKCSKHIF NAIKITKNEP ASADDFLPTL IYIVLKGNPP RLQSNIQYIT 240
  241 RFCNPSRLMT GEDGYYFTNL CCAVAFIEKL DAQSLNLSQE DFDRYMSGQT SPRKQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.221849
Match: 1txuA
Description: Crystal Structure of the Vps9 Domain of Rabex-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.248690472541603 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [396-491]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AESWSPDACL GVKQMYKNLD LLSQLNERQE RIMNEAKKLE KDLIDWTDGI AREVQDIVEK  60
   61 YPLEIKPPNQ PLAAIDSENV ENDKLPPPLQ PQVYAG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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