YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|2224593
Organism:	Homo sapiens
Length:	927 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2224593.

Description	E-value	Query Range	Subject Range
gi\|76648477 - gi\|76648477\|ref\|XP_881833.1\| PREDICTED: similar to Zinc finger protein 197 (ZnF20) isoform 4 [Bos ta...	0.0	[2..926]	[223..1155]
gi\|114671709 - gi\|114671709\|ref\|XP_511785.2\| PREDICTED: zinc finger protein 624 [Pan troglodytes]	0.0	[22..926]	[359..1264]
gi\|73984422 - gi\|73984422\|ref\|XP_855813.1\| PREDICTED: similar to Zinc finger protein 197 (ZnF20) isoform 6 [Canis ...	0.0	[2..926]	[222..1151]

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Predicted Domain #1

Region A:
Residues: [1-61]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVLSLESPLE KDPRVLGAQS VPRGRALKGL SPLGLDSAFR LFPDPRAGPW NTAVLSSGME  60
   61 P

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [62-163]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETALWGPDLQ GPEQSPNDAH RGAESENEEE SPRQESSGEE IIMGDPAQSP ESKDSTEMSL  60
   61 ERSSQDPSVP QNPPTPLGHS NPLDHQIPLD PPAPEVVPTP SD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [164-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WTKACEASWQ WGALTTWNSP PVVPANEPSL RELVQGRPAG AEKPYICNEC GKSFSQWSKL  60
   61 LRHQRIHTGE RPNTCSECGK SFTQSSHLVQ HQRTHTGEKP YKCPDCGKCF SWSSNLVQHQ 120
  121 RTHTGEKPYK CTECEKAFTQ STNLIKHQRS HTGEKPYKCG ECRRAFYRSS DLIQHQATHT 180
  181 GEKPYKCPEC GKRFGQNHNL LKHQKIHAG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	6.9
Match:	1tf6A
Description:	Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.47951889934838	bayes_pls_golite062009
nucleic acid binding	4.35187767955595	bayes_pls_golite062009
DNA binding	4.31051339571017	bayes_pls_golite062009
transcription factor activity	3.28758716579796	bayes_pls_golite062009
transcription repressor activity	3.07956158665183	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.96255357208943	bayes_pls_golite062009
protein binding	2.00293511941456	bayes_pls_golite062009
transcription activator activity	1.97757778483124	bayes_pls_golite062009
chromatin binding	1.91511881662436	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.35857850481346	bayes_pls_golite062009
structure-specific DNA binding	1.33097016250582	bayes_pls_golite062009
cytoskeletal protein binding	1.31750643711614	bayes_pls_golite062009
sequence-specific DNA binding	1.26862497534835	bayes_pls_golite062009
transcription factor binding	1.23738346570539	bayes_pls_golite062009
transcription corepressor activity	1.16887811832337	bayes_pls_golite062009
double-stranded DNA binding	1.00239065862819	bayes_pls_golite062009
tubulin binding	0.842454828267342	bayes_pls_golite062009
microtubule binding	0.72790523767509	bayes_pls_golite062009
transcription cofactor activity	0.627794176881836	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [373-570]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKPYRCTECG KSFIQSSELT QHQRTHTGEK PYECLECGKS FGHSSTLIKH QRTHLREDPF  60
   61 KCPVCGKTFT LSATLLRHQR THTGERPYKC PECGKSFSVS SNLINHQRIH RGERPYICAD 120
  121 CGKSFIMSST LIRHQRIHTG EKPYKCSDCG KSFIRSSHLI QHRRTHTGEK PYKCPECGKS 180
  181 FSQSSNLITH VRTHMDEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.69897
Match:	2i13A
Description:	No description for 2i13A was found.

Predicted Domain #5

Region A:
Residues: [571-680]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFVCSDCGKA FLEAHELEQH RVIHERGKTP ARRAQGDSLL GLGDPSLLTP PPGAKPHKCL  60
   61 VCGKGFNDEG IFMQHQRIHI GENPYKNADG LIAHAAPKPP QLRSPRLPFR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	6.4
Match:	2i13A
Description:	No description for 2i13A was found.

Predicted Domain #6

Region A:
Residues: [681-927]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNSYPGAAEG RAEAPGQPLK PPEGQEGFSQ RRGLLSSKTY ICSHCGESFL DRSVLLQHQL  60
   61 THGNEKPFLF PDYRIGLGEG AGPSPFLSGK PFKCPECKQS FGLSSELLLH QKVHAGGKSS 120
  121 QKSPELGKSS SVLLEHLRSP LGARPYRCSD CRASFLDRVA LTRHQETHTQ EKPPNPEDPP 180
  181 PEAVTLSTDQ EGEGETPTPT ESSSHGEGQN PKTLVEEKPY LCPECGAGFT EVAALLLHRS 240
  241 CHPGVSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.522879
Match:	1tf6A
Description:	Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
protein binding	2.05530362750351	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
structure-specific DNA binding	1.48624530884061	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
cytoskeletal protein binding	1.31662328614288	bayes_pls_golite062009
double-stranded DNA binding	1.18599503594288	bayes_pls_golite062009
tubulin binding	0.885027017225994	bayes_pls_golite062009
microtubule binding	0.780072635419707	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: