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View Structure Prediction Details

Protein: ATF7
Organism: Homo sapiens
Length: 494 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATF7.

Description E-value Query
Range
Subject
Range
gi|114581861, gi... - gi|114581863|ref|XP_001152299.1| PREDICTED: chimerin (chimaerin) 1 isoform 10 [Pan troglodytes], gi|...
2.0E-60 [1..424] [1..415]
gi|76617710 - gi|76617710|ref|XP_615033.2| PREDICTED: similar to Cyclic-AMP-dependent transcription factor ATF-7 (...
6.0E-57 [1..494] [1..494]
gi|73996193 - gi|73996193|ref|XP_848771.1| PREDICTED: similar to Cyclic-AMP-dependent transcription factor ATF-7 (...
2.0E-55 [1..494] [1..494]
gi|74185990, gi|... - gi|74185990|dbj|BAE34138.1| unnamed protein product [Mus musculus], gi|148672013|gb|EDL03960.1| acti...
8.0E-52 [1..494] [1..483]
gi|114644470 - gi|114644470|ref|XP_001137995.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
gi|208965794 - gi|208965794|dbj|BAG72911.1| activating transcription factor 7 [synthetic construct]
gi|28913, gi|119... - gi|5802980|ref|NP_006847.1| activating transcription factor 7 isoform 2 [Homo sapiens], gi|28913|emb...
2.0E-51 [1..494] [1..483]
ATF7_PONPY - Cyclic AMP-dependent transcription factor ATF-7 - Pongo pygmaeus (Orangutan)
ATF7_PONAB - Cyclic AMP-dependent transcription factor ATF-7 OS=Pongo abelii GN=ATF7 PE=2 SV=1
5.0E-51 [1..494] [1..483]
gi|109096956 - gi|109096956|ref|XP_001088758.1| PREDICTED: activating transcription factor 7, partial [Macaca mulat...
1.0E-48 [1..419] [1..419]

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Predicted Domain #1
Region A:
Residues: [1-98]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ TPTPTRFLKN  60
   61 CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1zr9A
Description: Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.5629554787463 bayes_pls_golite062009
binding 2.56065593409893 bayes_pls_golite062009
DNA binding 2.4518582111042 bayes_pls_golite062009
transcription regulator activity 2.37991313341667 bayes_pls_golite062009
transcription factor activity 1.5666937639803 bayes_pls_golite062009
protein binding 0.975412203442928 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.844177917146674 bayes_pls_golite062009
transcription activator activity 0.737716870305362 bayes_pls_golite062009
sequence-specific DNA binding 0.554760811774926 bayes_pls_golite062009
chromatin binding 0.429389462184423 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
transcription repressor activity 0.219901277043559 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.0696202830076269 bayes_pls_golite062009
transcription factor binding 0.0236725821766979 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAAAGPLDMS LPSTPDIKIK EEEPVEVDSS PPDSPASSPC SPPLKEKEVT PKPVLISTPT  60
   61 PTIVRPGSLP LHLGYDPLHP TLPSPTSVIT QAPPSNRQMG SPTGSLPLVM HLANGQTMPV 120
  121 LPGPPVQMPS VISLARPVSM 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [239-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPNIPGIPGP PVNSSGSISP SGHPIPSEAK MRLKATLTHQ VSSINGGCGM VVGTASTMVT  60
   61 ARPEQSQILI QHPDAPSPAQ PQVSPAQPTP STGGRR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [335-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRTVDEDPDE RRQRFLERNR AAASRCRQKR KLWVSSLEKK AEELTSQNIQ LSNEVTLLRN  60
   61 EVAQLKQLLL AHKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.221849
Match: 1t2kD
Description: Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [409-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPVTALQKKT QGYLESPKES SEPTGSPAPV IQHSSATAPS NGLSVRSAAE AVATSVLTQM  60
   61 ASQRTELSMP IQSHVIMTPQ SQSAGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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