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View Structure Prediction Details

Protein: PRSS1
Organism: Homo sapiens
Length: 247 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRSS1.

Description E-value Query
Range
Subject
Range
TRY2_RAT - Anionic trypsin-2 OS=Rattus norvegicus GN=Prss2 PE=1 SV=2
1.0E-79 [1..246] [1..246]
gi|4239965, gi|3... - gi|6755893|ref|NP_035776.1| trypsin 4 [Mus musculus], gi|4239965|dbj|BAA74761.1| pancreatic trypsin ...
6.0E-79 [1..246] [1..246]
gi|74355190 - gi|74355190|gb|AAI03999.1| PRSS1 protein [Homo sapiens]
6.0E-79 [1..247] [1..247]
gi|114051746, gi... - gi|58257848|gb|AAW69367.1| try16 [Macaca mulatta], gi|114051746|ref|NP_001040585.1| protease, serine...
6.0E-79 [1..247] [1..247]

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Predicted Domain #1
Region A:
Residues: [1-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS  60
   61 AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN 120
  121 ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT 180
  181 SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK 240
  241 NTIAANS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.0
Match: 1trnA
Description: Trypsin(ogen)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.91209560688646 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.52773635813967 bayes_pls_golite062009
serine hydrolase activity 5.5105092190926 bayes_pls_golite062009
serine-type peptidase activity 5.49703869306079 bayes_pls_golite062009
serine-type endopeptidase activity 5.39623690248556 bayes_pls_golite062009
endopeptidase activity 5.32070018460528 bayes_pls_golite062009
hydrolase activity 4.40346950809697 bayes_pls_golite062009
fucose binding 3.5000591397073 bayes_pls_golite062009
glycosaminoglycan binding 2.01328116441763 bayes_pls_golite062009
calcium-dependent protein binding 1.96509840108953 bayes_pls_golite062009
nucleic acid binding 1.73928761064649 bayes_pls_golite062009
DNA binding 1.61536775064425 bayes_pls_golite062009
heparin binding 1.48285358055737 bayes_pls_golite062009
thrombospondin receptor activity 1.44312413043539 bayes_pls_golite062009
catalytic activity 1.40927913545237 bayes_pls_golite062009
polysaccharide binding 1.34665327732001 bayes_pls_golite062009
binding 1.30738106455622 bayes_pls_golite062009
protein binding 1.30414885212044 bayes_pls_golite062009
receptor activity 1.10676631226741 bayes_pls_golite062009
serine-type aminopeptidase activity 0.964413112640311 bayes_pls_golite062009
signal transducer activity 0.885246794092463 bayes_pls_golite062009
molecular transducer activity 0.885246794092463 bayes_pls_golite062009
growth factor activity 0.848900101748605 bayes_pls_golite062009
receptor binding 0.79054390509229 bayes_pls_golite062009
calcium ion binding 0.753095272942721 bayes_pls_golite062009
sodium channel regulator activity 0.30724450617383 bayes_pls_golite062009

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