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View Structure Prediction Details

Protein: XPA
Organism: Homo sapiens
Length: 273 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XPA.

Description E-value Query
Range
Subject
Range
gi|60654147 - gi|60654147|gb|AAX29766.1| xeroderma pigmentosum complementation group A [synthetic construct]
1.0E-95 [1..273] [1..273]
gi|84579859, gi|... - gi|84579859|ref|NP_001033770.1| xeroderma pigmentosum, complementation group A [Bos taurus], gi|8375...
9.0E-95 [1..273] [1..273]
gi|7444282 - gi|7444282|pir||JG0190 XPA protein - human
2.0E-94 [1..273] [1..273]
gi|73971420 - gi|73971420|ref|XP_538745.2| PREDICTED: similar to DNA-repair protein complementing XP-A cells (Xero...
6.0E-92 [1..273] [1..273]
gi|109110874 - gi|109110874|ref|XP_001114093.1| PREDICTED: xeroderma pigmentosum, complementation group A [Macaca m...
2.0E-91 [1..273] [1..273]
XPA_MOUSE - DNA repair protein complementing XP-A cells homolog OS=Mus musculus GN=Xpa PE=1 SV=1
1.0E-89 [2..273] [4..272]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAADGALPE AAALEQPAEL PASVRASIER KRQRALMLRQ ARLAARPYSA TAAAATGGMA  60
   61 NV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [63-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAAPKIIDTG GGFILEEEEE EEQKIGKVVH QPGPVMEFDY VICEECGKEF MDSYLMNHFD  60
   61 LPTCDNCRDA DDKHKLITKT EAKQEYLLKD CDLEKREPPL KFIVKKNPHH SQWGDMKLYL 120
  121 KLQIVKRSLE VWGSQEALEE AKEVRQENRE KMKQKKFDKK VKELRRAVRS SVWKRETIVH 180
  181 QHEYGPEENL EDDMYRKTCT MCGHELTYEK M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 1xpaA
Description: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.3712591616364 bayes_pls_golite062009
transcription regulator activity 2.20400142735918 bayes_pls_golite062009
DNA binding 2.18702281581791 bayes_pls_golite062009
nucleic acid binding 2.04270847321412 bayes_pls_golite062009
transcription factor activity 1.44182975349714 bayes_pls_golite062009
protein binding 1.14219782236887 bayes_pls_golite062009
sequence-specific DNA binding 0.71242082351425 bayes_pls_golite062009
transcription activator activity 0.612819891085 bayes_pls_golite062009
structure-specific DNA binding 0.610805977602876 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.51536225088963 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.44426709732278 bayes_pls_golite062009
transcription factor binding 0.40850395411512 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.37925266318051 bayes_pls_golite062009
double-stranded DNA binding 0.280685154942276 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle