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View Structure Prediction Details

Protein: CDC37
Organism: Homo sapiens
Length: 378 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC37.

Description E-value Query
Range
Subject
Range
gi|60653087, gi|... - gi|60653087|gb|AAX29238.1| CDC37 cell division cycle 37-like [synthetic construct], gi|30585211|gb|A...
0.0 [1..378] [1..378]
gi|60820842 - gi|60820842|gb|AAX36551.1| CDC37 cell division cycle 37-like [synthetic construct]
gi|49457492 - gi|49457492|emb|CAG47045.1| CDC37 [Homo sapiens]
0.0 [1..378] [1..378]
gi|109123422 - gi|109123422|ref|XP_001105596.1| PREDICTED: CDC37 homolog [Macaca mulatta]
0.0 [1..378] [1..429]
CDC37_RAT - Hsp90 co-chaperone Cdc37 OS=Rattus norvegicus GN=Cdc37 PE=1 SV=2
0.0 [1..377] [1..378]
CDC37_MOUSE - Hsp90 co-chaperone Cdc37 OS=Mus musculus GN=Cdc37 PE=1 SV=1
0.0 [1..377] [1..378]
gi|73986801 - gi|73986801|ref|XP_854103.1| PREDICTED: similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein...
0.0 [1..377] [1..379]
CDC37_BOVIN - Hsp90 co-chaperone Cdc37 OS=Bos taurus GN=CDC37 PE=2 SV=1
0.0 [1..378] [1..380]
gi|51870491, gi|... - gi|51870491|emb|CAG15149.1| CDC37 cell division cycle 37 protein [Sus scrofa], gi|178057067|ref|NP_0...
gi|61553449 - gi|61553449|gb|AAX46408.1| CDC37 homolog [Bos taurus]
0.0 [1..377] [1..379]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK  60
   61 VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS 120
  121 KDGFSKSMVN T

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 60.251812
Match: PF03234.5
Description: No description for PF03234.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-378]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPEKTEEDSE EVREQKHKTF VEKYEKQIKH FGMLRRWDDS QKYLSDNVHL VCEETANYLV  60
   61 IWCIDLEVEE KCALMEQVAH QTIVMQFILE LAKSLKVDPR ACFRQFFTKI KTADRQYMEG 120
  121 FNDELEAFKE RVRGRAKLRI EKAMKEYEEE ERKKRLGPGG LDPVEVYESL PEELQKCFDV 180
  181 KDVQMLQDAI SKMDPTDAKY HMQRCIDSGL WVPNSKASEA KEGEEAGPGD PLLEAVPKTG 240
  241 DEKDVSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 97.522879
Match: 1us7B
Description: Complex of Hsp90 and P50
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.63059449218992 bayes_pls_golite062009
protein binding 0.967371813449539 bayes_pls_golite062009
unfolded protein binding 0.68193901105298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle