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View Structure Prediction Details

Protein: HIST1H1A
Organism: Homo sapiens
Length: 215 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIST1H1A.

Description E-value Query
Range
Subject
Range
gi|70878483 - gi|70878483|gb|EAN91735.1| trans-sialidase, putative [Trypanosoma cruzi]
gi|71649745 - gi|71649745|ref|XP_813586.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
1.0E-28 [2..214] [752..964]
gi|22209012 - gi|22209012|gb|AAC98688.2| surface antigen PHGST#5 [Trypanosoma cruzi]
4.0E-23 [4..212] [479..687]
gi|116126363, gi... - gi|118786522|ref|XP_315475.3| ENSANGP00000021721 [Anopheles gambiae str. PEST], gi|116126363|gb|EAA1...
1.0E-21 [3..212] [1040..1254]
gi|76639353 - gi|76639353|ref|XP_607274.2| PREDICTED: similar to neurofilament, heavy polypeptide 200kDa isoform 1...
6.0E-21 [3..214] [594..806]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETVPPAPA ASAAPEKPLA GKKAKKPAKA AAASKKKPAG PSVSELIVQA ASSSKERGGV  60
   61 SLAALKKALA AAGYDVEKNN SRIKLGIKSL VSKGTLVQTK GTGASGSFKL NKKASSVETK 120
  121 PGAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 1hstA
Description: Histone H5, globular domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVATKTKATG ASKKLKKATG ASKKSVKTPK KAKKPAATRK SSKNPKKPKT VKPKKVAKSP  60
   61 AKAKAVKPKA AKARVTKPKT AKPKKAAPKK K

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.47
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle