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View Structure Prediction Details

Protein: HIST1H1C
Organism: Homo sapiens
Length: 213 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIST1H1C.

Description E-value Query
Range
Subject
Range
gi|17154501 - gi|17154501|emb|CAD12824.1| FHA protein [Bordetella pertussis]
2.0E-25 [2..212] [3259..3461]
gi|70878483 - gi|70878483|gb|EAN91735.1| trans-sialidase, putative [Trypanosoma cruzi]
gi|71649745 - gi|71649745|ref|XP_813586.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
4.0E-23 [2..212] [1135..1349]
gi|116126363, gi... - gi|118786522|ref|XP_315475.3| ENSANGP00000021721 [Anopheles gambiae str. PEST], gi|116126363|gb|EAA1...
7.0E-23 [11..212] [1019..1225]
gi|601931 - gi|601931|gb|AAA57153.1| neurofilament-H
1.0E-22 [3..213] [54..265]
gi|6650634 - gi|6650634|gb|AAB94077.2| adhesin [Bordetella bronchiseptica]
4.0E-22 [2..212] [3293..3497]
gi|111548666, gi... - gi|119568221|gb|EAW47836.1| SNF2 histone linker PHD RING helicase, isoform CRA_a [Homo sapiens], gi|...
1.0E-21 [31..206] [433..626]
gi|24020878, gi|... - gi|50979202|ref|NP_001003352.1| neurofilament, heavy polypeptide 200kDa [Canis lupus familiaris], gi...
2.0E-21 [2..213] [567..793]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETAPAAPA AAPPAEKAPV KKKAAKKAGG TPRKASGPPV SELITKAVAA SKERSGVSLA  60
   61 ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.154902
Match: 1ghcA
Description: HOMO-AND HETERONUCLEAR TWO-DIMENSIONAL NMR STUDIES OF THE GLOBULAR DOMAIN OF HISTONE H1: FULL ASSIGNMENT, TERTIARY STRUCTURE, AND COMPARISON WITH THE GLOBULAR DOMAIN OF HISTONE H5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEAKPKVKK AGGTKPKKPV GAAKKPKKAA GGATPKKSAK KTPKKAKKPA AATVTKKVAK  60
   61 SPKKAKVAKP KKAAKSAAKA VKPKAAKPKV VKPKKAAPKK K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle