YRC Public Data Repository - Protein Structure Prediction

Protein:	TIMP3
Organism:	Homo sapiens
Length:	211 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIMP3.

Description	E-value	Query Range	Subject Range
gi\|60654097, gi\|... - gi\|61365712\|gb\|AAX42751.1\| tissue inhibitor of metalloproteinase 3 [synthetic construct], gi\|6136570...	6.0E-91	[1..211]	[1..211]
TIMP3_HORSE - Metalloproteinase inhibitor 3 OS=Equus caballus GN=TIMP3 PE=2 SV=1	1.0E-90	[1..211]	[1..211]
tr\|M3XE72\|M3XE72... - TIMP metallopeptidase inhibitor 3 OS=Felis catus GN=TIMP3 PE=4 SV=1 gi\|73969248 - gi\|73969248\|ref\|XP_538410.2\| PREDICTED: similar to tissue inhibitor of metalloproteinase 3 isoform 1...	1.0E-90	[1..211]	[1..211]
TIMP3_BOVIN - Metalloproteinase inhibitor 3 OS=Bos taurus GN=TIMP3 PE=2 SV=1	2.0E-90	[1..211]	[1..211]
TIMP3_MOUSE - Metalloproteinase inhibitor 3 OS=Mus musculus GN=Timp3 PE=1 SV=1	2.0E-88	[1..211]	[1..211]
gi\|66911017, gi\|... - gi\|67972654\|ref\|NP_037018.2\| TIMP metallopeptidase inhibitor 3 [Rattus norvegicus], gi\|66911017\|gb\|A...	3.0E-88	[1..211]	[1..211]
TIMP3_CHICK - Metalloproteinase inhibitor 3 OS=Gallus gallus GN=TIMP3 PE=1 SV=2	5.0E-88	[1..211]	[1..212]

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Predicted Domain #1

Region A:
Residues: [1-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPWLGLIVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK LVKEGPFGTL  60
   61 VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY QYLLTGRVYD GKMYTGLCNF 120
  121 VERWDQLTLS QRKGLNYRYH LGCNCKIKSC YYLPCFVTSK NECLWTDMLS NFGYPGYQSK 180
  181 HYACIRQKGG YCSWYRGWAP PDKSIINATD P

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.0
Match:	1br9A
Description:	HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
metalloendopeptidase inhibitor activity	7.17434748400899	bayes_pls_golite062009
metalloenzyme regulator activity	7.17434748400899	bayes_pls_golite062009
metalloenzyme inhibitor activity	7.17434748400899	bayes_pls_golite062009
peptidase inhibitor activity	3.93668549411033	bayes_pls_golite062009
endopeptidase inhibitor activity	3.90361447859652	bayes_pls_golite062009
enzyme regulator activity	2.05189175806105	bayes_pls_golite062009
protein binding	2.04187591727985	bayes_pls_golite062009
receptor binding	1.79096938850925	bayes_pls_golite062009
cytokine activity	1.72828967672993	bayes_pls_golite062009
binding	1.57363735103063	bayes_pls_golite062009
enzyme inhibitor activity	1.54714635439345	bayes_pls_golite062009
G-protein-coupled receptor binding	0.6932827058439	bayes_pls_golite062009
chemokine activity	0.59253057522745	bayes_pls_golite062009
chemokine receptor binding	0.59253057522745	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: