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View Structure Prediction Details

Protein: USF2
Organism: Homo sapiens
Length: 346 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for USF2.

Description E-value Query
Range
Subject
Range
gi|109124486 - gi|109124486|ref|XP_001111345.1| PREDICTED: similar to LISCH protein isoform 1 [Macaca mulatta]
4.0E-70 [13..346] [389..722]
gi|49168494 - gi|49168494|emb|CAG38742.1| USF2 [Homo sapiens]
3.0E-68 [1..346] [1..346]
USF2_MOUSE - Upstream stimulatory factor 2 OS=Mus musculus GN=Usf2 PE=1 SV=1
USF2_RAT - Upstream stimulatory factor 2 OS=Rattus norvegicus GN=Usf2 PE=1 SV=2
2.0E-66 [1..346] [1..346]
gi|34420907, gi|... - gi|47564070|ref|NP_001001162.1| upstream stimulatory factor 2 [Bos taurus], gi|34420907|gb|AAQ18903....
1.0E-65 [1..346] [1..346]
IPI:IPI00990983.... - Uncharacterized protein OS=Mus musculus GN=Usf2, Tax_Id=10090 Gene_Symbol=Usf2 Uncharacterized prote...
gi|11994804 - gi|11994804|dbj|BAB19965.1| USF2 splicing variant-1 [Rattus norvegicus]
2.0E-59 [1..346] [1..319]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMLDPGLDP AASATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA ITSVQQAAFG  60
   61 DHNIQYQFRT ETNGGQVTYR VVQVTDGQLD GQGDTAGAVS VVSTAAFAGG QQAVTQVGVD 120
  121 GAAQRPGPAA ASVPPGPAAP FPLAVIQNPF SNGGSPAAEA VSGEARFAYF PASSVGDTTA 180
  181 VSVQTTDQSL QAGGQFYVMM TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [231-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRDERRRAQH NEVERRRRDK INNWIVQLSK IIPDCNADNS KTGASKGGIL SKACDYIREL  60
   61 RQTNQRMQET FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GEGTRQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1an4A
Description: Usf B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
structure-specific DNA binding 1.44875612483512 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
double-stranded DNA binding 1.350302919253 bayes_pls_golite062009
sterol response element binding 1.09947841348213 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle