YRC Public Data Repository - Protein Structure Prediction

Protein:	CENPA
Organism:	Homo sapiens
Length:	140 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CENPA.

Description	E-value	Query Range	Subject Range
gi\|88943485 - gi\|88943485\|ref\|XP_497711.2\| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]	2.0E-55	[5..135]	[53..178]
gi\|76612880 - gi\|76612880\|ref\|XP_871849.1\| PREDICTED: similar to H3 histone, family 2 isoform 2 [Bos taurus]	8.0E-53	[5..135]	[215..340]
gi\|74003971, gi\|... - gi\|74003975\|ref\|XP_859248.1\| PREDICTED: similar to histone 1, H2ai (predicted) isoform 3 [Canis fami...	1.0E-51	[5..135]	[9..134]
gi\|50729226 - gi\|50729226\|ref\|XP_425464.1\| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]	1.0E-51	[5..135]	[72..197]
gi\|109508757, gi... - gi\|109508757\|ref\|XP_001075226.1\| PREDICTED: similar to H3 histone, family 3B [Rattus norvegicus], gi...	3.0E-51	[6..135]	[26..150]
gi\|116057937 - gi\|116057937\|emb\|CAL54140.1\| Histones H3 and H4 (ISS) [Ostreococcus tauri]	5.0E-51	[6..135]	[40..164]
gi\|77548740, gi\|... - gi\|77548740\|gb\|ABA91537.1\| histone H3 [Oryza sativa (japonica cultivar-group)], gi\|62701879\|gb\|AAX92...	7.0E-51	[5..134]	[9..133]

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Predicted Domain #1

Region A:
Residues: [1-140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE IRKLQKSTHL  60
   61 LIRKLPFSRL AREICVKFTR GVDFNWQAQA LLALQEAAEA FLVHLFEDAY LLTLHAGRVT 120
  121 LFPKDVQLAR RIRGLEEGLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.39794
Match:	1u35A
Description:	Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.581886805340955	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: