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View Structure Prediction Details

Protein: PAX7
Organism: Homo sapiens
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAX7.

Description E-value Query
Range
Subject
Range
gi|76666870 - gi|76666870|ref|XP_877127.1| PREDICTED: similar to Paired box protein Pax-3 isoform 8 [Bos taurus]
2.0E-59 [1..268] [1..273]
gi|109477586, gi... - gi|109477586|ref|XP_001071787.1| PREDICTED: similar to paired box gene 7 [Rattus norvegicus], gi|109...
5.0E-58 [1..468] [1..466]
PAX7_MOUSE - Paired box protein Pax-7 OS=Mus musculus GN=Pax7 PE=1 SV=2
gi|162319578, gi... - gi|162319578|gb|AAI56885.1| Paired box gene 7 [synthetic construct], gi|162318458|gb|AAI56073.1| Pai...
1.0E-57 [1..468] [1..466]
gi|111307754, gi... - gi|7524359|ref|NP_039236.1| paired box 7 isoform 2 [Homo sapiens], gi|2570014|emb|CAA65521.1| PAX7 [...
2.0E-57 [1..520] [1..518]
gi|108998498 - gi|108998498|ref|XP_001091237.1| PREDICTED: similar to paired box gene 7 isoform 2 isoform 2 [Macaca...
3.0E-57 [1..520] [1..518]
gi|114554358 - gi|114554358|ref|XP_513156.2| PREDICTED: paired box gene 7 isoform 2 [Pan troglodytes]
2.0E-56 [1..520] [1..518]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALPGTVPR MMRPAPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP LPNHIRHKIV  60
   61 EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA IGGSKPRQVA TPDVEKKIEE 120
  121 YKRENPGMFS WEIRDRLLKD GHCDRSTVPS GLVSSISRVL RIKFGKKEEE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
cytoskeletal protein binding 0.768149315604243 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
actin binding 0.0864629297513302 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [171-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEADKKEDDG EKKAKHSIDG ILGDKGNRLD EGSDVESEPD LPLKRKQRRS RTTFTAEQLE  60
   61 ELEKAFERTH YPDIYTREEL AQRTKLTEAR VQVWFSNRRA RWRKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
cytoskeletal protein binding 0.768149315604243 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
protein deacetylase activity 0.0943601066056998 bayes_pls_golite062009
actin binding 0.0864629297513302 bayes_pls_golite062009
histone deacetylase activity 0.0802156998596484 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [276-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGANQLAAFN HLLPGGFPPT GMPTLPPYQL PDSTYPTTTI SQDGGSTVHR PQPLPPSTMH  60
   61 QGGLAAAAAA ADTSSAYGAR HSFSSY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [362-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDSFMNPAAP SNHMNPVSNG LSPQVMSILG NPSAVPPQPQ ADFSISPLHG GLDSATSISA  60
   61 SCSQRADSIK PGDSLPTSQA YCPPTYSTTG YSVDPVAGYQ YGQYGQSECL VPWASPVPIP 120
  121 SPTPRASCLF MESYKVVSGW GMSISQMEKL KSSQMEQFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle