YRC Public Data Repository - Protein Structure Prediction

Protein:	PPM1A
Organism:	Homo sapiens
Length:	382 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPM1A.

Description	E-value	Query Range	Subject Range
gi\|73963080 - gi\|73963080\|ref\|XP_852144.1\| PREDICTED: similar to protein phosphatase 1A isoform 1 isoform 3 [Canis...	0.0	[1..376]	[1..376]
PPM1A_BOVIN - Protein phosphatase 1A OS=Bos taurus GN=PPM1A PE=2 SV=1	0.0	[1..382]	[1..382]
PPM1A_RABIT - Protein phosphatase 1A OS=Oryctolagus cuniculus GN=PPM1A PE=2 SV=1	0.0	[1..382]	[1..382]
gi\|114653333 - gi\|114653333\|ref\|XP_001167412.1\| PREDICTED: hypothetical protein LOC452950 isoform 8 [Pan troglodyte...	0.0	[1..382]	[49..430]
PPM1A_RAT - Protein phosphatase 1A OS=Rattus norvegicus GN=Ppm1a PE=1 SV=1	0.0	[1..382]	[1..382]
PPM1A_MOUSE - Protein phosphatase 1A OS=Mus musculus GN=Ppm1a PE=1 SV=1	0.0	[1..382]	[1..382]
gi\|50748830 - gi\|50748830\|ref\|XP_421422.1\| PREDICTED: similar to protein phosphatase 2C alpha; PP2Calpha [Gallus g...	0.0	[1..382]	[1..382]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD  60
   61 GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 120
  121 GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180
  181 SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 240
  241 IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE 300
  301 AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 360
  361 VYNRLNPYKN DDTDSTSTDD MW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	115.0
Match:	1a6qA
Description:	CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.46633224572308	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.25564034681743	bayes_pls_golite062009
protein serine/threonine phosphatase activity	6.20846750257603	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.62997267604309	bayes_pls_golite062009
hydrolase activity	2.93014592649821	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
signal transducer activity	1.61688496161233	bayes_pls_golite062009
molecular transducer activity	1.61688496161233	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	1.47578617076714	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: