YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|4505573, gi\|1...
Organism:	Homo sapiens
Length:	646 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|4505573, gi|1....

Description	E-value	Query Range	Subject Range
gi\|114650706 - gi\|114650706\|ref\|XP_509742.2\| PREDICTED: Rho guanine nucleotide exchange factor 7 [Pan troglodytes]	0.0	[1..646]	[256..901]
gi\|40788881 - gi\|40788881\|dbj\|BAA09763.2\| KIAA0142 [Homo sapiens]	0.0	[1..646]	[157..802]
gi\|2098783 - gi\|2098783\|gb\|AAB57691.1\| p85SPR [Mus musculus]	0.0	[1..646]	[1..646]
gi\|73989539 - gi\|73989539\|ref\|XP_542671.2\| PREDICTED: similar to Rho guanine nucleotide exchange factor 7 isoform ...	0.0	[1..646]	[248..952]
ARHG7_RAT - Rho guanine nucleotide exchange factor 7 OS=Rattus norvegicus GN=Arhgef7 PE=1 SV=1	0.0	[1..646]	[1..646]
gi\|50730554 - gi\|50730554\|ref\|XP_416958.1\| PREDICTED: similar to Rho guanine nucleotide exchange factor 7 (PAK-int...	0.0	[125..646]	[749..1270]

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Predicted Domain #1

Region A:
Residues: [1-73]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG RTGWFPSNYV  60
   61 REVKASEKPV SPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.69897
Match:	1zsgA
Description:	beta PIX-SH3 complexed with an atypical peptide from alpha-PAK
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [74-163]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGTLKSPPKG FDTTAINKSY YNVVLQNILE TENEYSKELQ TVLSTYLRPL QTSEKLSSAN  60
   61 ISYLMGNLEE ICSFQQMLVQ SLEECTKLPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.39794
Match:	1by1A
Description:	beta-pix
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase regulator activity	5.11074603459714	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	5.08847923392129	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	4.86840565991411	bayes_pls_golite062009
small GTPase regulator activity	4.48792387237937	bayes_pls_golite062009
enzyme regulator activity	4.3439350617225	bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity	4.34078803610551	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	4.20362774065877	bayes_pls_golite062009
binding	2.72918942472263	bayes_pls_golite062009
protein binding	1.55620082928053	bayes_pls_golite062009
signal transducer activity	1.38049306661118	bayes_pls_golite062009
molecular transducer activity	1.38049306661118	bayes_pls_golite062009
GTPase activator activity	0.752349454878473	bayes_pls_golite062009
receptor binding	0.540147469472769	bayes_pls_golite062009
transcription regulator activity	0.535089791137297	bayes_pls_golite062009
enzyme activator activity	0.453716946272335	bayes_pls_golite062009
Ras GTPase activator activity	0.451744196693003	bayes_pls_golite062009
small GTPase binding	0.40881922277547	bayes_pls_golite062009
nucleic acid binding	0.401233613072731	bayes_pls_golite062009
GTPase binding	0.38955577404416	bayes_pls_golite062009
DNA binding	0.313566245805362	bayes_pls_golite062009
cytoskeletal protein binding	0.27856999050234	bayes_pls_golite062009
Rho GTPase activator activity	0.211048635764309	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [164-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQQRVGGCFL NLMPQMKTLY LTYCANHPSA VNVLTEHSEE LGEFMETKGA SSPGILVLTT  60
   61 GLSKPFMRLD KYPTLLKELE RHMEDYHTDR QDIQKSMAAF KNLSAQCQEV RKRKELELQI 120
  121 LTEAIRNW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.30103
Match:	2hwoA
Description:	No description for 2hwoA was found.

Predicted Domain #4

Region A:
Residues: [292-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGDDIKTLGN VTYMSQVLIQ CAGSEEKNER YLLLFPNVLL MLSASPRMSG FIYQGKLPTT  60
   61 GMTITKLEDS ENHRNAFEIS GSMIERILVS CNNQQDLQEW VEHLQKQTKV TS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.154902
Match:	1v61A
Description:	Solution Structure of the Pleckstrin Homology Domain of alpha-Pix
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.29080729281876	bayes_pls_golite062009
protein binding	2.12168271674167	bayes_pls_golite062009
GTPase regulator activity	1.66986263418539	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.64990514605397	bayes_pls_golite062009
signal transducer activity	1.55319485371003	bayes_pls_golite062009
molecular transducer activity	1.55319485371003	bayes_pls_golite062009
small GTPase regulator activity	1.2550809703725	bayes_pls_golite062009
enzyme regulator activity	1.25381967078645	bayes_pls_golite062009
profilin binding	1.13790597338922	bayes_pls_golite062009
protein domain specific binding	0.90578029954417	bayes_pls_golite062009
transporter activity	0.882299675921716	bayes_pls_golite062009
small GTPase binding	0.8507658747425	bayes_pls_golite062009
GTPase binding	0.82889812790119	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.745321902095093	bayes_pls_golite062009
cytoskeletal protein binding	0.570303292760019	bayes_pls_golite062009
receptor binding	0.50127063593663	bayes_pls_golite062009
substrate-specific transporter activity	0.47853225730469	bayes_pls_golite062009
receptor activity	0.353510125274044	bayes_pls_golite062009
transcription regulator activity	0.324566338715835	bayes_pls_golite062009
actin binding	0.3076498786796	bayes_pls_golite062009
transmembrane receptor activity	0.207829786337892	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity	0.13700176999256	bayes_pls_golite062009
DNA binding	0.136435190086451	bayes_pls_golite062009
nucleic acid binding	0.118897432176337	bayes_pls_golite062009
receptor signaling protein activity	0.10105990547756	bayes_pls_golite062009
beta-amyloid binding	0.0597358198128299	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [404-558]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGNPTIKPHS VPSHTLPSHP VTPSSKHADS KPAPLTPAYH TLPHPSHHGT PHTTINWGPL  60
   61 EPPKTPKPWS LSCLRPAPPL RPSAALCYKE DLSKSPKTMK KLLPKRKPER KPSDEEFASR 120
  121 KSTAALEEDA QILKVIEAYC TSAKTRQTLN SSSRK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.373	N/A	N/A	a.1.1	Globin-like
View	Download	0.260	N/A	N/A	a.1.1	Globin-like
View	Download	0.235	N/A	N/A	a.1.1	Globin-like
View	Download	0.219	N/A	N/A	a.1.1	Globin-like
View	Download	0.217	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain

Predicted Domain #6

Region A:
Residues: [559-646]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESAPQVLLPE EEKIIVEETK SNGQTVIEEK SLVDTVYALK DEVQELRQDN KKMKKSLEEE  60
   61 QRARKDLEKL VRKVLKNMND PAWDETNL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.704	N/A	N/A	a.2.6	Effector domain of the protein kinase pkn/prk1
View	Download	0.655	N/A	N/A	a.7.1	Spectrin repeat
View	Download	0.583	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.533	N/A	N/A	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.441	N/A	N/A	f.17.1	F1F0 ATP synthase subunit C

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: