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View Structure Prediction Details

Protein: PRKRA
Organism: Homo sapiens
Length: 313 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRKRA.

Description E-value Query
Range
Subject
Range
gi|74004908 - gi|74004908|ref|XP_545545.2| PREDICTED: similar to protein kinase, interferon-inducible double stran...
gi|194043952 - gi|194043952|ref|XP_001927740.1| PREDICTED: similar to protein kinase, interferon-inducible double s...
5.0E-65 [1..313] [1..313]
PRKRA_MOUSE - Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Mus musculus GN=Prk...
2.0E-64 [1..313] [1..313]
gi|62901980 - gi|62901980|gb|AAY18941.1| DKFZp564I0123 [synthetic construct]
2.0E-64 [3..313] [27..337]
PRKRA_RAT - Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Rattus norvegicus G...
4.0E-64 [1..313] [1..313]
PRKRA_BOVIN - Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Bos taurus GN=PRKRA...
4.0E-64 [1..313] [1..313]
gi|62897775 - gi|62897775|dbj|BAD96827.1| protein kinase, interferon-inducible double stranded RNA dependent activ...
8.0E-64 [1..313] [1..313]
gi|109100226 - gi|109100226|ref|XP_001098583.1| PREDICTED: similar to protein kinase, interferon-inducible double s...
8.0E-61 [17..313] [6..302]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ  60
   61 IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 2dixA
Description: No description for 2dixA was found.

Predicted functions:

Term Confidence Notes
RNA binding 5.07736605479017 bayes_pls_golite062009
double-stranded RNA binding 3.47197996469543 bayes_pls_golite062009
nucleic acid binding 3.18496581088988 bayes_pls_golite062009
structural constituent of ribosome 3.14632751635044 bayes_pls_golite062009
siRNA binding 2.97216972787792 bayes_pls_golite062009
structural molecule activity 2.6585058058337 bayes_pls_golite062009
binding 2.65564350773346 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
ribonuclease III activity 2.17541496872253 bayes_pls_golite062009
DNA binding 1.55609377953134 bayes_pls_golite062009
protein kinase activity 1.5033075536308 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.47352121883517 bayes_pls_golite062009
kinase activity 1.3977924791267 bayes_pls_golite062009
transcription regulator activity 1.32350001817922 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 1.22831298721384 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.19693457490298 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.927536998997123 bayes_pls_golite062009
transcription repressor activity 0.803014306451579 bayes_pls_golite062009
protein serine/threonine kinase activity 0.755902465799696 bayes_pls_golite062009
transferase activity 0.616475820485559 bayes_pls_golite062009
mRNA binding 0.404665180963566 bayes_pls_golite062009
single-stranded RNA binding 0.35650576095599 bayes_pls_golite062009
transcription factor activity 0.298820022613881 bayes_pls_golite062009
RNA helicase activity 0.0112094156505713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [118-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKQPKNQLNP IGSLQELAIH HGWRLPEYTL SQEGGPAHKR EYTTICRLES FMETGKGASK  60
   61 KQAKRNAAEK FLAKFSNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.39794
Match: 2cpnA
Description: Solution structure of the second dsRBD of TAR RNA-binding protein 2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [196-313]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPENHISLTN VVGHSLGCTW HSLRNSPGEK INLLKRSLLS IPNTDYIQLL SEIAKEQGFN  60
   61 ITYLDIDELS ANGQYQCLAE LSTSPITVCH GSGISCGNAQ SDAAHNALQY LKIIAERK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.154902
Match: 1qu6A
Description: dsRNA-dependent protein kinase pkr
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.07736605479017 bayes_pls_golite062009
double-stranded RNA binding 3.47197996469543 bayes_pls_golite062009
nucleic acid binding 3.18496581088988 bayes_pls_golite062009
structural constituent of ribosome 3.14632751635044 bayes_pls_golite062009
siRNA binding 2.97216972787792 bayes_pls_golite062009
structural molecule activity 2.6585058058337 bayes_pls_golite062009
binding 2.65564350773346 bayes_pls_golite062009
protein binding 2.48364477869915 bayes_pls_golite062009
ribonuclease III activity 2.17541496872253 bayes_pls_golite062009
DNA binding 1.55609377953134 bayes_pls_golite062009
protein kinase activity 1.5033075536308 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.47352121883517 bayes_pls_golite062009
kinase activity 1.3977924791267 bayes_pls_golite062009
transcription regulator activity 1.32350001817922 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 1.22831298721384 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.19693457490298 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.927536998997123 bayes_pls_golite062009
transcription repressor activity 0.803014306451579 bayes_pls_golite062009
protein serine/threonine kinase activity 0.755902465799696 bayes_pls_golite062009
transferase activity 0.616475820485559 bayes_pls_golite062009
mRNA binding 0.404665180963566 bayes_pls_golite062009
single-stranded RNA binding 0.35650576095599 bayes_pls_golite062009
transcription factor activity 0.298820022613881 bayes_pls_golite062009
RNA helicase activity 0.0112094156505713 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle