YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: HNRNPH1
Organism: Homo sapiens
Length: 449 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPH1.

Description E-value Query
Range
Subject
Range
gi|73976787 - gi|73976787|ref|XP_857499.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
3.0E-61 [1..446] [1..447]
gi|76689285 - gi|76689285|ref|XP_881509.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
6.0E-61 [1..446] [1..447]

Back

Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE  60
   61 LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 2db1A
Description: No description for 2db1A was found.

Predicted Domain #2
Region A:
Residues: [110-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGFVRLRGLP FGCSKEEIVQ FFSGLEIVPN GITLPVDFQG RSTGEAFVQF ASQEIAEKAL  60
   61 KKHKERIGHR YIEIFKSSRA EVRTHYDPPR KLMAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1wg5A
Description: Solution structure of the first RRM domain in heterogeneous nuclear ribonucleoprotein H
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
4.67888641618755 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
snRNA binding 1.76821382294389 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
U1 snRNA binding 0.612226940931031 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [205-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRPGPYDRPG AGRGYNSIGR GAGFERMRRG AYGGGYGGYD DYNGYNDGYG FGSDRFGRDL  60
   61 NYCFSGMSDH RYGDGGSTFQ STT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.24
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [288-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHCVHMRGLP YRATENDIYN FFSPLNPVRV HIEIGPDGRV TGEADVEFAT HEDAVAAMSK  60
   61 DKANMQHRYV ELFLNSTAGA SGGAYEHRYV ELFLNSTAGA SGGAYGSQMM GGMGLSNQSS 120
  121 YGGPASQQLS GGYGGGYGGQ SSMSGYDQVL QENSSDFQSN IA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2hgnA
Description: No description for 2hgnA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle