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View Structure Prediction Details

Protein: DPB2
Organism: Saccharomyces cerevisiae
Length: 689 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPB2.

Description E-value Query
Range
Subject
Range
DPB2 - Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chro...
0.0 [1..689] [4..692]
DPB2_ASHGO - DNA polymerase epsilon subunit B OS=Ashbya gossypii GN=DPB2 PE=3 SV=1
DPB2_ASHGO - DNA polymerase epsilon subunit B OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NR...
0.0 [5..689] [4..677]
gi|40742829, gi|... - gi|67900904|ref|XP_680708.1| hypothetical protein AN7439.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
0.0 [6..673] [33..725]
gi|28950027 - gi|28950027|emb|CAD70782.1| related to DNA directed DNA polymerase II chain B [Neurospora crassa]
0.0 [7..675] [75..831]
gi|42547282, gi|... - gi|46136767|ref|XP_390075.1| hypothetical protein FG09899.1 [Gibberella zeae PH-1], gi|42547282|gb|E...
0.0 [7..682] [48..769]
orf19.7564 - DPB2 CGDID:CAL0000130 Assembly 19, Contig19-2518 (46094, 43968) CDS, reverse complemented, translate...
gi|46441139, gi|... - gi|68473041|ref|XP_719326.1| potential DNA polymerase epsilon subunit [Candida albicans SC5314], gi|...
0.0 [8..688] [6..707]
POLE2 - polymerase (DNA directed), epsilon 2 (p59 subunit)
0.0 [89..687] [4..524]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGSGNVLPV KIQPPLLRPL AYRVLSRKYG LSIKSDGLSA LAEFVGTNIG ANWRQGPATI  60
   61 KFLEQFAAVW KQQERGLFID QSGVKEVIQE MKEREKVEWS HEHPIQHEEN ILGRTDDDEN 120
  121 NSDDEMPIAA DSSLQNVSLS SPMRQPTERD EYKQPFKPES SKALDWRDYF KVINASQQQR 180
  181 FSYNPHKMQF IFVPNKKQNG LGGIAGFLPD IEDKVQMFLT RYYLTNDRVM RNENF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [236-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNSDMFNPLS SMVSLQNELS NTNRQQQSSS MSITPIKNLL GRDAQNFLLL GLLNKNFKGN  60
   61 WSLEDPSGSV EIDISQTIPT QGHYYVPGCM VLVEGIYYSV GNKFHVTSMT LPPGERREIT 120
  121 LETIGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.421 N/A N/A b.1.18 E set domains
View Download 0.411 N/A N/A b.60.1 Lipocalins
View Download 0.383 N/A N/A b.55.1 PH domain-like
View Download 0.360 N/A N/A d.20.1 UBC-like
View Download 0.350 N/A N/A b.63.1 Oncogene products

Predicted Domain #3
Region A:
Residues: [362-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLLGIHGIS NNNFIARLDK DLKIRLHLLE KELTDHKFVI LGANLFLDDL KIMTALSKIL  60
   61 QKLNDDPPTL LIWQGSFTSV PVFASMSSRN ISSSTQFKNN FDALATLLSR FDNLTENTTM 120
  121 IFIPGPNDLW GSMVSLGASG TLPQDPIPSA FTKKINKVCK NVVWSSNPTR IAYLSQEIVI 180
  181 FRDDLSGRFK RHRLEFPFNE SEDVYTENDN MMSKDTDIVP IDELVK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transferase activity, transferring phosphorus-containing groups 3.253873361615 bayes_pls_golite062009
transferase activity 2.86536343515876 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.60559887605086 bayes_pls_golite062009
phosphatase activity 2.32143054924462 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.29895042460743 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.25451947416972 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.69489536786659 bayes_pls_golite062009
binding 1.50157839850353 bayes_pls_golite062009
catalytic activity 1.30037658165549 bayes_pls_golite062009
structural molecule activity 0.371786873304259 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.33393888611713 bayes_pls_golite062009
kinase activity 0.308698487135154 bayes_pls_golite062009
protein binding 0.30363127120976 bayes_pls_golite062009
protein kinase activity 0.108241336192419 bayes_pls_golite062009
hydrolase activity 0.070797330694107 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [588-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPDQLPQKVQ ETRKLVKTIL DQGHLSPFLD SLRPISWDLD HTLTLCPIPS TMVLCDTTSA  60
   61 QFDLTYNGCK VINPGSFIHN RRARYMEYVP SSKKTIQEEI YI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle