YRC Public Data Repository - Protein Structure Prediction

Protein:	ESS1
Organism:	Saccharomyces cerevisiae
Length:	170 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESS1.

Description	E-value	Query Range	Subject Range
ESS1_YEAST - Peptidyl-prolyl cis-trans isomerase ESS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... ESS1 - Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residue...	3.0E-43	[1..170]	[1..170]
gi\|44981286, gi\|... - gi\|45185568\|ref\|NP_983284.1\| ACL120Wp [Ashbya gossypii ATCC 10895], gi\|44981286\|gb\|AAS51108.1\| ACL12... gi\|44981286 - gi\|44981286\|gb\|AAS51108.1\| ACL120Wp [Ashbya gossypii ATCC 10895]	4.0E-35	[5..168]	[1..161]
gi\|41152183, gi\|... - gi\|41152183\|ref\|NP_957042.1\| protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 [Danio...	2.0E-34	[5..170]	[1..159]
gi\|10120798 - gi\|10120798\|pdb\|1F8A\|B Chain B, Structural Basis For The Phosphoserine-Proline Recognition By Group ...	9.0E-34	[5..169]	[5..166]
gi\|7259613, gi\|1... - gi\|7259613\|gb\|AAF43897.1\|AF239760_1 prolyl isomerase Pin1 [Xenopus laevis], gi\|148227870\|ref\|NP_0010...	5.0E-33	[5..169]	[1..158]
gi\|49097644, gi\|... - gi\|67539950\|ref\|XP_663749.1\| hypothetical protein AN6145.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	1.0E-32	[5..168]	[5..179]
gi\|6468202, gi\|6... - gi\|6468202\|dbj\|BAA87038.1\| PIN1 [Mus sp.], gi\|6468200\|dbj\|BAA87037.1\| PIN1 [Mus sp.] PIN1_MOUSE - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Mus musculus GN=Pin1 PE=1 SV=1 gi\|55716013 - gb\|AAH86125.1\| Unknown (protein for MGC:98527) [Xenopus laevis]	2.0E-32	[5..169]	[1..164]
PIN1_SCHPO - Peptidyl-prolyl cis-trans isomerase pin1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=p... pin1 - peptidyl-prolyl cis-trans isomerase Pin1	7.0E-32	[6..168]	[1..173]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSDVASRTG LPTPWTVRYS KSKKREYFFN PETKHSQWEE PEGTNKDQLH KHLRDHPVRV  60
   61 RCLHILIKHK DSRRPASHRS ENITISKQDA TDELKTLITR LDDDSKTNSF EALAKERSDC 120
  121 SSYKRGGDLG WFGRGEMQPS FEDAAFQLKV GEVSDIVESG SGVHVIKRVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1f8aB_
Description:	Mitotic rotamase PIN1; Mitotic rotamase PIN1, domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidyl-prolyl cis-trans isomerase activity	4.0615867467963	bayes_pls_golite062009
cis-trans isomerase activity	3.99265212272703	bayes_pls_golite062009
transcription regulator activity	2.64797495383748	bayes_pls_golite062009
isomerase activity	2.31710030777753	bayes_pls_golite062009
transcription activator activity	2.28375305944516	bayes_pls_golite062009
transcription factor binding	2.18630749239417	bayes_pls_golite062009
transcription cofactor activity	2.07432061489599	bayes_pls_golite062009
transcription coactivator activity	2.02433252968502	bayes_pls_golite062009
transcription repressor activity	1.81795522051605	bayes_pls_golite062009
macrolide binding	1.71427500929512	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68688812199737	bayes_pls_golite062009
kinase activity	1.67904764195462	bayes_pls_golite062009
binding	1.63170667962375	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57898291235576	bayes_pls_golite062009
FK506 binding	1.49236065710546	bayes_pls_golite062009
protein kinase activity	1.45320632553313	bayes_pls_golite062009
transferase activity	1.34122735969662	bayes_pls_golite062009
transcription corepressor activity	0.911388717587011	bayes_pls_golite062009
catalytic activity	0.885282592863018	bayes_pls_golite062009
transcription elongation regulator activity	0.75548957875935	bayes_pls_golite062009
protein serine/threonine kinase activity	0.671059013500415	bayes_pls_golite062009
SMAD binding	0.325741923624893	bayes_pls_golite062009
unfolded protein binding	0.27473817613726	bayes_pls_golite062009
protein binding	0.0371998661994551	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: