YRC Public Data Repository - Protein Structure Prediction

Protein:	PAN6
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAN6.

Description	E-value	Query Range	Subject Range
PANC_THEMA - Pantothenate synthetase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=... PANC_THEMA - Pantothenate synthetase OS=Thermotoga maritima GN=panC PE=1 SV=1	0.0	[1..309]	[1..279]
PAN6 - Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid bio... gi\|151943021 - gi\|151943021\|gb\|EDN61356.1\| pantothenate synthase [Saccharomyces cerevisiae YJM789] PANC_YEAST - Pantoate--beta-alanine ligase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN6 PE=1 ...	0.0	[1..309]	[1..309]
PANC_THENE - Pantothenate synthetase OS=Thermotoga neapolitana GN=panC PE=3 SV=1	0.0	[1..309]	[1..279]
PANC_PSESM - Pantothenate synthetase OS=Pseudomonas syringae pv. tomato GN=panC PE=3 SV=1 gi\|213925030, gi... - gi\|213970149\|ref\|ZP_03398280.1\| pantoate--beta-alanine ligase [Pseudomonas syringae pv. tomato T1], ... PANC_PSESM - Pantothenate synthetase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=panC PE=3 SV=1	0.0	[5..307]	[2..278]
PANC_PSEPK - Pantothenate synthetase OS=Pseudomonas putida (strain KT2440) GN=panC PE=3 SV=1	0.0	[5..309]	[2..280]
tr\|F2K5M2\|F2K5M2... - Pantothenate synthetase OS=Pseudomonas brassicacearum (strain NFM421) GN=panC PE=3 SV=1 gi\|28932737 - gi\|28932737\|gb\|AAO60161.1\| pantoate-beta-alanine ligase; PanC [Pseudomonas fluorescens]	0.0	[5..307]	[2..278]
gi\|27262518 - gi\|27262518\|gb\|AAN87540.1\| Pantoate--beta-alanine ligase [Heliobacillus mobilis]	0.0	[1..309]	[27..305]
PANC_PSEAB - Pantothenate synthetase OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=panC PE=3 SV=1 PANC_PSEAE - Pantothenate synthetase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 122... gi\|254238533, gi... - gi\|84317389\|ref\|ZP_00965837.1\| COG0414: Panthothenate synthetase [Pseudomonas aeruginosa C3719], gi\|... gi\|107103829 - gi\|107103829\|ref\|ZP_01367747.1\| hypothetical protein PaerPA_01004900 [Pseudomonas aeruginosa PACS2] PANC_PSEAE - Pantothenate synthetase OS=Pseudomonas aeruginosa GN=panC PE=3 SV=1	0.0	[5..309]	[2..280]
PANC1_BRADU - Pantothenate synthetase 1 OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 1479... PANC1_BRAJA, PAN... - Pantoate--beta-alanine ligase - Bradyrhizobium japonicum, Pantothenate synthetase 1 OS=Bradyrhizobiu...	0.0	[1..309]	[1..278]
PANC_AQUAE - Pantothenate synthetase OS=Aquifex aeolicus (strain VF5) GN=panC PE=3 SV=1 PANC_AQUAE - Pantothenate synthetase OS=Aquifex aeolicus GN=panC PE=3 SV=1	0.0	[8..306]	[6..277]

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Predicted Domain #1

Region A:
Residues: [1-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIFHTVEEV VQWRTQELRE TRFRETIGFV PTMGCLHSGH ASLISQSVKE NTYTVVSIFV  60
   61 NPSQFAPTED LDNYPRTLPD DIKLLESLKV DVLFAPNAHV MYPQGIPLDI EEQKGPFVSV 120
  121 LGLSEKLEGK TRPNFFRGVA TVVTKLFNIV MADVAYFGQK DIQQFIVLQC MVDELFVNTR 180
  181 LQMMPIVRNN NGLALSSRNK YLCPESLKIS ENLYRGLKAA ENAIRRLAPG GRLSRSEIID 240
  241 TVTQIWAPYV DSHDFKIDYV SLADFKTLDE LSDVENTSEQ QPIVISCAVY VTDREKPDTV 300
  301 VRLIDNIVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0
Match:	1ihoA_
Description:	Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	5.66762539052452	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	5.66762539052452	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	5.65398773296369	bayes_pls_golite062009
ligase activity	4.61911329839139	bayes_pls_golite062009
pantoate-beta-alanine ligase activity	2.65346774278189	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.21467185575886	bayes_pls_golite062009
nucleic acid binding	1.64840822019417	bayes_pls_golite062009
methionine-tRNA ligase activity	1.59260025359667	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.47110858685627	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.38579849961344	bayes_pls_golite062009
pantetheine-phosphate adenylyltransferase activity	1.25694296916214	bayes_pls_golite062009
binding	1.11291710031577	bayes_pls_golite062009
adenylyltransferase activity	1.08055019963499	bayes_pls_golite062009
transferase activity	1.06817715108743	bayes_pls_golite062009
tryptophan-tRNA ligase activity	0.725178047574893	bayes_pls_golite062009
arginine-tRNA ligase activity	0.722005407734432	bayes_pls_golite062009
nicotinate-nucleotide adenylyltransferase activity	0.692499879958128	bayes_pls_golite062009
nicotinamide-nucleotide adenylyltransferase activity	0.567882194154248	bayes_pls_golite062009
nucleotidyltransferase activity	0.564359271862248	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.430902479559327	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: