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View Structure Prediction Details

Protein: TCF3
Organism: Homo sapiens
Length: 654 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCF3.

Description E-value Query
Range
Subject
Range
TFE2_MESAU - Transcription factor E2-alpha OS=Mesocricetus auratus GN=TCF3 PE=3 SV=1
296.0 [0..1] [654..2]
gi|181906 - gi|181906|gb|AAA52331.1| e12 protein [Homo sapiens]
296.0 [0..7] [654..1]
TFE2_MOUSE - Transcription factor E2-alpha OS=Mus musculus GN=Tcf3 PE=1 SV=2
293.0 [0..1] [654..2]
gi|78214343 - gi|78214343|ref|NP_598208.2| transcription factor E2a isoform a [Rattus norvegicus]
292.0 [0..1] [654..2]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQPQRMAPV GTDKELSDLL DFSMMFPLPV TNGKGRPASL AGAQFGGSGL EDRPSSGSWG  60
   61 SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG KSGERGAYAS FGRDAGVGGL 120
  121 TQAGFLSGEL ALNSPGPLSP SGMKGTSQYY PSYSGSSRRR AADGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDTQPKKVRK VPPGLPSSVY PPSSGEDYGR DATAYPSAKT PSSTYPAPFY VADGSLHPSA  60
   61 ELWSPPGQAG FGPMLGGGSS PLPLPPGSGP VGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSSSTFGGL HQHERMGYQL HGAEVNGGLP SASSFSSAPG ATYGGVSSHT PPVSGADSLL  60
   61 GSRGTTAGSS GDALGKALAS IYSPDHSSNN FSSSPSTPVG SPQGLAGTSQ WPRAGAPGAL 120
  121 SPSYDGGLHG LQSKIEDH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [397-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDEAIHVLRS HAVGTAGDMH TLLPGHGALA SGFTGPMSLG GRHAGLVGGS HPEDGLAGST  60
   61 SLMHNHAALP SQPGTLPDLS RPPDSYSGLG RAGATAAASE IKREEKEDEE NTSAADHSEE 120
  121 EKKELKAPRA RTSPDEDEDD LL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [539-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEQKAEREK ERRVANNARE RLRVRDINEA FKELGRMCQL HLNSEKPQTK LLILHQAVSV  60
   61 ILNLEQQVRE RNLNPKAACL KRREEEKVSG VVGDPQMVLS APHPGLSEAH NPAGHM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.02
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle