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View Structure Prediction Details

Protein: TCF3
Organism: Homo sapiens
Length: 654 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TCF3.

Description E-value Query
Range
Subject
Range
TFE2_MESAU - Transcription factor E2-alpha OS=Mesocricetus auratus GN=TCF3 PE=3 SV=1
296.0 [0..1] [654..2]
gi|181906 - gi|181906|gb|AAA52331.1| e12 protein [Homo sapiens]
296.0 [0..7] [654..1]
TFE2_MOUSE - Transcription factor E2-alpha OS=Mus musculus GN=Tcf3 PE=1 SV=2
293.0 [0..1] [654..2]
gi|78214343 - gi|78214343|ref|NP_598208.2| transcription factor E2a isoform a [Rattus norvegicus]
292.0 [0..1] [654..2]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQPQRMAPV GTDKELSDLL DFSMMFPLPV TNGKGRPASL AGAQFGGSGL EDRPSSGSWG  60
   61 SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG KSGERGAYAS FGRDAGVGGL 120
  121 TQAGFLSGEL ALNSPGPLSP SGMKGTSQYY PSYSGSSRRR AADGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDTQPKKVRK VPPGLPSSVY PPSSGEDYGR DATAYPSAKT PSSTYPAPFY VADGSLHPSA  60
   61 ELWSPPGQAG FGPMLGGGSS PLPLPPGSGP VGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSSSTFGGL HQHERMGYQL HGAEVNGGLP SASSFSSAPG ATYGGVSSHT PPVSGADSLL  60
   61 GSRGTTAGSS GDALGKALAS IYSPDHSSNN FSSSPSTPVG SPQGLAGTSQ WPRAGAPGAL 120
  121 SPSYDGGLHG LQSKIEDH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [397-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDEAIHVLRS HAVGTAGDMH TLLPGHGALA SGFTGPMSLG GRHAGLVGGS HPEDGLAGST  60
   61 SLMHNHAALP SQPGTLPDLS RPPDSYSGLG RAGATAAASE IKREEKEDEE NTSAADHSEE 120
  121 EKKELKAPRA RTSPDEDEDD LL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [539-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEQKAEREK ERRVANNARE RLRVRDINEA FKELGRMCQL HLNSEKPQTK LLILHQAVSV  60
   61 ILNLEQQVRE RNLNPKAACL KRREEEKVSG VVGDPQMVLS APHPGLSEAH NPAGHM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.02
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle