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View Structure Prediction Details

Protein: PZF1
Organism: Saccharomyces cerevisiae
Length: 429 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PZF1.

Description E-value Query
Range
Subject
Range
gi|18916833 - gi|18916833|dbj|BAB85555.1| KIAA1969 protein [Homo sapiens]
0.0 [4..384] [202..576]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGEVLNNEG MPLAELKQET IPISRSESSE SLNSLTSTRS SSSNRPKTYF CDYDGCDKAF  60
   61 TRPSILTEHQ LSVHQGLRAF QCDKCAKSFV KKSHLERHLY THSDTKPFQC SYCGKGVTTR 120
  121 QQLKRHEVTH TKSFICPEEG CNLRFYKHPQ LRAHILSVHL HKLTCPHCNK SFQRPYRLRN 180
  181 HISKHHDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 156.68867
Match: 1ubdC_
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [189-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVENPYQCTF AGCCKEFRIW SQLQSHIKND HPKLKCPICS KPCVGENGLQ MHMIIHDDSL  60
   61 VTKNWKCHIC PDMSFSRKHD LLTHYGSIHT EEDIPLELKY KISDIQQLVQ DHGVQLGNSK 120
  121 HSNEQDEEKI SNRLRKRRKL TENNNVEFLQ NEVDLEKRLE SG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [351-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENGLNLLLNT VGRKYRCFYN NCSRTFKTKE KYEKHIDKHK VHELKLKILQ EKEENKTLVD  60
   61 QNHKEPFIIQ KETQSAGDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.722 b.34.2 SH3-domain
View Download 0.733 d.15.1 Ubiquitin-like
View Download 0.783 d.15.8 Translation initiation factor IF3, N-terminal domain
View Download 0.751 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.737 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.716 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.650 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.612 b.71.1 Glycosyl hydrolase domain
View Download 0.607 b.55.1 PH domain-like
View Download 0.602 b.1.18 E set domains
View Download 0.532 c.47.1 Thioredoxin-like
View Download 0.524 d.175.1 Penicillin binding protein dimerisation domain
View Download 0.512 d.15.1 Ubiquitin-like
View Download 0.511 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.495 b.7.2 Periplasmic chaperone C-domain
View Download 0.492 d.15.1 Ubiquitin-like
View Download 0.464 g.35.1 HIPIP (high potential iron protein)
View Download 0.454 b.55.1 PH domain-like
View Download 0.435 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.427 c.55.4 Translational machinery components
View Download 0.421 d.93.1 SH2 domain
View Download 0.375 b.61.2 Metalloprotease inhibitor
View Download 0.369 d.170.2 A heparin-binding domain
View Download 0.353 g.10.1 Hairpin loop containing domain-like
View Download 0.347 c.52.1 Restriction endonuclease-like
View Download 0.327 b.55.1 PH domain-like
View Download 0.305 c.51.2 TolB, N-terminal domain
View Download 0.280 b.60.1 Lipocalins
View Download 0.271 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.269 b.55.1 PH domain-like
View Download 0.266 d.70.1 Yest killer toxins
View Download 0.264 b.55.1 PH domain-like
View Download 0.233 b.61.2 Metalloprotease inhibitor
View Download 0.232 b.80.3 Cell-division inhibitor MinC, C-terminal domain
View Download 0.230 b.55.1 PH domain-like
View Download 0.229 b.38.1 Sm-like ribonucleoproteins
View Download 0.225 d.110.4 SNARE-like
View Download 0.220 b.34.2 SH3-domain
View Download 0.208 b.50.1 Acid proteases

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
nucleic acid binding 4.35187767955595 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
transcription repressor activity 3.07956158665183 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.96255357208943 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
chromatin binding 1.91511881662436 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.35857850481346 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
transcription corepressor activity 1.16887811832337 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
transcription coactivator activity 0.781519259241993 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle