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View Structure Prediction Details

Protein: GPH1
Organism: Saccharomyces cerevisiae
Length: 902 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPH1.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [40..900] [1..830]
gi|5305433, gi|4... - gi|5305433|gb|AAD41649.1|AF073177_1 glycogen phosphorylase [Drosophila melanogaster], gi|4689102|gb|...
0.0 [40..900] [1..830]
gi|33874902 - gi|33874902|gb|AAH09895.2| PYGL protein [Homo sapiens]
0.0 [35..900] [19..852]
PHSH_SOLTU - Alpha-glucan phosphorylase, H isozyme OS=Solanum tuberosum PE=1 SV=1
0.0 [58..901] [17..835]
gi|442605, gi|44... - gi|442608|pdb|1ABB|D Chain D, Control Of Phosphorylase B Conformation By A Modified Cofactor: Crysta...
0.0 [50..900] [1..820]
PYGB_MOUSE - Glycogen phosphorylase, brain form OS=Mus musculus GN=Pygb PE=1 SV=3
0.0 [40..900] [1..830]
gi|7433822 - pir||S77252 phosphorylase (EC 2.4.1.1) 2 - Synechocystis sp. (strain PCC 6803)
gi|1652666, gi|1... - gi|1652666|dbj|BAA17586.1| glycogen phosphorylase [Synechocystis sp. PCC 6803], gi|16330178|ref|NP_4...
0.0 [44..901] [21..841]

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Predicted Domain #1
Region A:
Residues: [1-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPASTSTTN DMITEEPTSP HQIPRLTRRL TGFLPQEIKS IDTMIPLKSR ALWNKHQVKK  60
   61 FNKAEDFQDR FIDHVETTLA RSLYNCDDMA AYEAASMSIR DNLVIDWNKT QQKFTTRDPK 120
  121 RVYYLSLEFL MGRALDNALI NMKIEDPEDP AASKGKPREM IKGALDDLGF KLEDVLDQEP 180
  181 DAGLGNGGLG RLAACFVDSM ATEGIPAWGY GLRYEYGIF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [232-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDYWLNSGNP WEIERNEVQI PVTFYGYVDR PEGGKTTLSA SQWIGGERVL AVAYDFPVPG  60
   61 FKTSNVNNLR LWQARPTTEF DFAKFNNGDY KNSVAQQQRA ESITAVLYPN DNFAQGKELR 120
  121 LKQQYFWCAA SLHDILRRFK KSKRPWTEFP DQVAIQLNDT HPTLAIVELQ RVLVDLEKLD 180
  181 WHEAWDIVTK TFAYTNHTVM QEALEKWPVG LFGHLLPRHL EIIYDINWFF LQDVAKKFPK 240
  241 DVDLLSRISI IEENSPERQI RMAFLAIVGS HKVNGVAELH SELIKTTIFK DFVKFYGPSK 300
  301 FVNVTNGITP RRWLKQ

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [882-902]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSSDRCIEEY SDTIWNVEPV T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1a8i__
Description: Glycogen phosphorylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glycogen phosphorylase activity 5.43556332287206 bayes_pls_golite062009
phosphorylase activity 4.4363209226962 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
glucosyltransferase activity 2.11024512158394 bayes_pls_golite062009
UDP-glucosyltransferase activity 1.84595685206241 bayes_pls_golite062009
transferase activity 1.47703555225615 bayes_pls_golite062009
binding 1.22341386111754 bayes_pls_golite062009
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 0.849686864309466 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 0.690032302126686 bayes_pls_golite062009
sugar binding 0.68155433315706 bayes_pls_golite062009
hydrolase activity 0.507333921449805 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.354187614795831 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009
drug binding 0.102804615007901 bayes_pls_golite062009
protein binding 0.0755094482594821 bayes_pls_golite062009
carboxylic acid binding 0.00262987576299967 bayes_pls_golite062009
carbohydrate phosphatase activity 4.32270241054966E-4 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [220-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQKIIDGYQV ET

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [548-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANPSLAKLIS ETLNDPTEEY LLDMAKLTQL GKYVEDKEFL KKWNQVKLNN KIRLVDLIKK  60
   61 ENDGVDIINR EYLDDTLFDM QVKRIHEYKR QQLNVFGIIY RYLAMKNMLK NGASIEEVAK 120
  121 KYPRKVSIFG GKSAPGYYMA KLIIKLINCV ADIVNNDESI EHLLKVVFVA DYNVSKAEII 180
  181 IPASDLSEHI STAGTEASGT SNMKFVMNGG LIIGTVDGAN VEITREIGED NVFLFGNLSE 240
  241 NVEELRYNHQ YHPQDLPSSL DSVLSYIESG QFSPENPNEF KPLVDSIKYH GDYYLVSDDF 300
  301 ESYLATHELV DQEFHNQRSE WLKKSVLSVA NVGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 1a8i__
Description: Glycogen phosphorylase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle