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View Structure Prediction Details

Protein: URN1
Organism: Saccharomyces cerevisiae
Length: 465 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URN1.

Description E-value Query
Range
Subject
Range
URN1_YEAST - Pre-mRNA-splicing factor URN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URN1 PE=1 ...
URN1 - Putative protein of unknown function containing WW and FF domains; overexpression causes accumulatio...
0.0 [1..465] [1..465]
gi|6329166, gi|9... - ref|NP_062385.1| transcription elongation regulator 1 (CA150) [Mus musculus], gi|6329166|dbj|BAA863...
6.0E-69 [3..410] [435..849]
TCERG1 - transcription elongation regulator 1
2.0E-67 [3..410] [433..847]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-67 [3..410] [433..847]
gi|15636898 - gi|15636898|dbj|BAB68206.1| formin binding protein 11-related protein [Gallus gallus]
3.0E-67 [2..410] [302..700]
gi|8656003 - gi|8656003|gb|AAF78276.1|AC020576_20 Contains similarity to formin binding protein 11 from Mus muscu...
4.0E-65 [3..407] [193..607]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGEWQEFKT PAGKKYYYNK NTKQSRWEKP NLKKGSNLES NAKESQTERK PTFSLELVNG  60
   61 WHLIIYNDGT KLYFNDDSKE FKNDISQEDD SRCRSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.228787
Match: 1o6wA_
Description: Splicing factor prp40
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.24368858184725 bayes_pls_golite062009
protein binding 0.261137474693717 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [97-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IESLDKEKLV LLIGVARGYT MREEDIDKIL ESCNEEIHLF KRNQDEVERK DEISEEAGDV  60
   61 KSPLQESHTG LVSGYGSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.605 c.47.1 Thioredoxin-like
View Download 0.637 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.485 a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.638 a.60.11 Hypothetical protein YjbJ
View Download 0.638 a.60.11 Hypothetical protein YjbJ
View Download 0.637 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.605 c.47.1 Thioredoxin-like
View Download 0.603 c.47.1 Thioredoxin-like
View Download 0.485 a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.467 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.444 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.438 c.47.1 Thioredoxin-like
View Download 0.435 a.36.1 Signal peptide-binding domain
View Download 0.417 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.405 a.55.1 IHF-like DNA-binding proteins
View Download 0.393 a.60.2 RuvA domain 2-like
View Download 0.387 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.371 d.95.2 Homing endonucleases
View Download 0.365 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.358 a.1.1 Globin-like
View Download 0.343 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.341 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.339 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.335 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.334 a.60.8 HRDC-like
View Download 0.328 a.4.1 Homeodomain-like
View Download 0.323 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.307 a.4.5 "Winged helix" DNA-binding domain
View Download 0.301 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.292 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.286 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.285 d.58.7 RNA-binding domain, RBD
View Download 0.273 a.17.1 p8-MTCP1
View Download 0.264 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.264 a.126.1 Serum albumin-like
View Download 0.260 d.40.1 CI-2 family of serine protease inhibitors
View Download 0.254 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.253 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.248 a.5.2 UBA-like
View Download 0.246 a.61.1 Retroviral matrix proteins
View Download 0.242 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.238 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.237 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.236 a.130.1 Chorismate mutase II
View Download 0.232 d.58.4 Dimeric alpha+beta barrel
View Download 0.229 a.61.1 Retroviral matrix proteins
View Download 0.229 a.74.1 Cyclin-like
View Download 0.227 a.29.4 RecG, N-terminal domain
View Download 0.222 c.47.1 Thioredoxin-like
View Download 0.212 b.82.3 cAMP-binding domain-like
View Download 0.203 a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.202 a.74.1 Cyclin-like

Predicted Domain #3
Region A:
Residues: [175-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEEDEEEDE EEDEENEEQI VNQDISIIDD LNRIDTDDID ERNIFFELFD RYKLDKFSTW  60
   61 SLQSKKIEND PDFYKIRDDT VRESLFEEWC GERSGNATAE ESDSEDNSED DSEVLEPTKY 120
  121 HYLAQIVANA GTIAPDTI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.221849
Match: 1h40A_
Description: Hypa/FBP11

Predicted Domain #4
Region A:
Residues: [313-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQDIRKQQKA LYKAYKIKEY IPSKRDQDKF VSQLLFYYKT FDLEQRKEIF CDCLRDHERD  60
   61 FTGAVESLRQ DKELIDRWQT LLKAPADSSS IEDILLSIEH RCCVSPIVVT EPRYYVVGIL 120
  121 EKTVVWVRWL AAEVGPSSRF TPVGAGNEPI NPE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [343-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSQLLFYYKT FDLEQRKEIF CDCLRDHERD FTGAVESLRQ DKELIDRWQT LLKAPADSSS  60
   61 IEDILLSIEH RCCVSPIVVT EPRYYVVGIL EKTVVWVRWL AAEVGPSSRF TPVGAGNEPI 120
  121 NPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 2doeA
Description: No description for 2doeA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle