YRC Public Data Repository - Protein Structure Prediction

Protein:	RPN7
Organism:	Saccharomyces cerevisiae
Length:	429 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPN7.

Description	E-value	Query Range	Subject Range
RPN7 - Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae reg... gi\|151942884 - gi\|151942884\|gb\|EDN61230.1\| proteasome regulatory particle subunit [Saccharomyces cerevisiae YJM789] gi\|190408035 - gi\|190408035\|gb\|EDV11300.1\| 26S proteasome regulatory subunit RPN7 [Saccharomyces cerevisiae RM11-1a... RPN7_YEAST - 26S proteasome regulatory subunit RPN7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...	3.0E-74	[1..429]	[1..429]
PSMD6_MOUSE - 26S proteasome non-ATPase regulatory subunit 6 OS=Mus musculus GN=Psmd6 PE=1 SV=1	6.0E-74	[12..423]	[5..389]
gi\|208965390 - gi\|208965390\|dbj\|BAG72709.1\| proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 [synthetic c... ENSPTRT00000028219 - null PSMD6 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	6.0E-74	[12..423]	[5..389]
gi\|27694784, gi\|... - gi\|27694784\|gb\|AAH43825.1\| P44s10-prov protein [Xenopus laevis], gi\|147904380\|ref\|NP_001080462.1\| hy...	4.0E-73	[12..423]	[5..389]
gi\|29436940, gi\|... - gi\|41053583\|ref\|NP_956585.1\| proteasome, 26S, non-ATPase regulatory subunit 6 [Danio rerio], gi\|2943...	1.0E-69	[12..423]	[5..386]
Rpn7-PA - The gene Rpn7 is referred to in FlyBase by the symbol Dmel\Rpn7 (CG5378, FBgn0028688). It is a prote... gi\|220956106 - gi\|220956106\|gb\|ACL90596.1\| Rpn7-PA [synthetic construct] gi\|194200351, gi... - gi\|195572882\|ref\|XP_002104424.1\| GD18456 [Drosophila simulans], gi\|194200351\|gb\|EDX13927.1\| GD18456 ...	6.0E-68	[12..422]	[5..388]
PSMD6_ARATH - 26S proteasome non-ATPase regulatory subunit 6 homolog OS=Arabidopsis thaliana GN=RPN7 PE=1 SV=1	2.0E-66	[21..423]	[10..387]
gi\|125548775 - gi\|125548775\|gb\|EAY94597.1\| hypothetical protein OsI_16374 [Oryza sativa Indica Group] PSMD6_ORYSJ - 26S proteasome non-ATPase regulatory subunit 6 OS=Oryza sativa subsp. japonica GN=RPN7 PE=2 SV=1 PSMD6_ORYSA, PSD... - 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory particle non-ATPase subuni...	2.0E-66	[21..423]	[12..389]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-65	[21..423]	[10..406]
gi\|85085957 - gi\|85085957\|ref\|XP_957611.1\| hypothetical protein NCU03972 [Neurospora crassa OR74A] gi\|32405356, gi\|... - gi\|32405356\|ref\|XP_323291.1\| hypothetical protein [Neurospora crassa], gi\|28918704\|gb\|EAA28375.1\| hy...	3.0E-65	[15..428]	[4..491]

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Predicted Domain #1

Region A:
Residues: [1-90]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDVEEKSQE VEYVDPTVNR VPNYEVSEKA FLLTQSKVSI EQRKEAAEFV LAKIKEEEMA  60
   61 PYYKYLCEEY LVNNGQSDLE HDEKSDSLNE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [91-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WIKFDQELYN ELCKKNESKI KELNEKIQKL EEDDEGELEQ AQAWINLGEY YAQIGDKDNA  60
   61 EKTLGKSLSK AISTGAKIDV MLTIARLGFF YNDQLYVKEK LEAVNSMIEK GGDWERRNRY 120
  121 KTYYGIHCLA VRNFKEAAKL LVDSLATFTS IELTSYESIA TYASVTGLFT LERTDLKSKV 180
  181 I

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.39794
Match:	1na0A_
Description:	Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [272-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSPELLSLIS TTAALQSISS LTISLYASDY ASYFPYLLET YANVLIPCKY LNRHADFFVR  60
   61 EMRRKVYAQL LESYKTLSLK SMASAFGVSV AFLDNDLGKF IPNKQLNCVI DRVNGIVETN 120
  121 RPDNKNAQYH LLVKQGDGLL TKLQKYGAAV RLTGSDRV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [319-429]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CKYLNRHADF FVREMRRKVY AQLLESYKTL SLKSMASAFG VSVAFLDNDL GKFIPNKQLN  60
   61 CVIDRVNGIV ETNRPDNKNA QYHLLVKQGD GLLTKLQKYG AAVRLTGSDR V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.045757
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits