YRC Public Data Repository - Protein Structure Prediction

Protein:	PRE2
Organism:	Saccharomyces cerevisiae
Length:	287 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE2.

Description	E-value	Query Range	Subject Range
gi\|151942879 - gi\|151942879\|gb\|EDN61225.1\| proteasome subunit [Saccharomyces cerevisiae YJM789] PSB5_YEAST - Proteasome subunit beta type-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRE2 PE=1... gi\|190408030 - gi\|190408030\|gb\|EDV11295.1\| proteasome subunit [Saccharomyces cerevisiae RM11-1a] PRE2 - Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome	7.0E-81	[1..287]	[1..287]
gi\|18157533 - gi\|18157533\|dbj\|BAB83848.1\| PSMB8-A [Oryzias latipes]	8.0E-73	[30..277]	[29..272]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	2.0E-72	[46..272]	[4..234]
gi\|4545092, gi\|4... - gi\|47522620\|ref\|NP_999100.1\| proteasome beta 8 subunit [Sus scrofa], gi\|4545092\|gb\|AAD22390.1\|AF0594...	6.0E-72	[31..277]	[13..257]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-71	[3..280]	[4..278]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	2.0E-71	[46..273]	[4..235]
PSB8_RAT - Proteasome subunit beta type-8 OS=Rattus norvegicus GN=Psmb8 PE=1 SV=3	6.0E-71	[31..277]	[24..268]
gi\|972988, gi\|97... - gi\|972988\|gb\|AAA75036.1\| 20S proteasome subunit Lmp7 [Mus musculus], gi\|972986\|gb\|AAA75035.1\| 20S pr...	6.0E-71	[31..277]	[29..273]
gi\|18124203 - gi\|18124203\|gb\|AAL59862.1\|AF363583_1 proteasome beta-subunit LMP7 [Heterodontus francisci]	6.0E-71	[26..280]	[21..272]

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Predicted Domain #1

Region A:
Residues: [1-65]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAIADSFSV PNRLVKELQY DNEQNLESDF VTGASQFQRL APSLTVPPIA SPQQFLRAHT  60
   61 DDSRN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [66-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDCKIKIAHG TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA  60
   61 DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQY KGAGLSMGTM ICGYTRKEGP 120
  121 TIYYVDSDGT RLKGDIFCVG SGQTFAYGVL DSNYKWDLSV EDALYLGKRS ILAAAHRDAY 180
  181 SGGSVNLYHV TEDGWIYHGN HDVGELFWKV KEEEGSFNNV IG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1302.69897
Match:	1g0uK_
Description:	Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits