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View Structure Prediction Details

Protein: PRE2
Organism: Saccharomyces cerevisiae
Length: 287 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE2.

Description E-value Query
Range
Subject
Range
gi|151942879 - gi|151942879|gb|EDN61225.1| proteasome subunit [Saccharomyces cerevisiae YJM789]
PSB5_YEAST - Proteasome subunit beta type-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRE2 PE=1...
gi|190408030 - gi|190408030|gb|EDV11295.1| proteasome subunit [Saccharomyces cerevisiae RM11-1a]
PRE2 - Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
7.0E-81 [1..287] [1..287]
gi|18157533 - gi|18157533|dbj|BAB83848.1| PSMB8-A [Oryzias latipes]
8.0E-73 [30..277] [29..272]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1
PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1
2.0E-72 [46..272] [4..234]
gi|4545092, gi|4... - gi|47522620|ref|NP_999100.1| proteasome beta 8 subunit [Sus scrofa], gi|4545092|gb|AAD22390.1|AF0594...
6.0E-72 [31..277] [13..257]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-71 [3..280] [4..278]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ...
PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1
2.0E-71 [46..273] [4..235]
PSB8_RAT - Proteasome subunit beta type-8 OS=Rattus norvegicus GN=Psmb8 PE=1 SV=3
6.0E-71 [31..277] [24..268]
gi|972988, gi|97... - gi|972988|gb|AAA75036.1| 20S proteasome subunit Lmp7 [Mus musculus], gi|972986|gb|AAA75035.1| 20S pr...
6.0E-71 [31..277] [29..273]
gi|18124203 - gi|18124203|gb|AAL59862.1|AF363583_1 proteasome beta-subunit LMP7 [Heterodontus francisci]
6.0E-71 [26..280] [21..272]

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Predicted Domain #1
Region A:
Residues: [1-65]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAIADSFSV PNRLVKELQY DNEQNLESDF VTGASQFQRL APSLTVPPIA SPQQFLRAHT  60
   61 DDSRN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.679 a.4.1 Homeodomain-like
View Download 0.478 a.60.2 RuvA domain 2-like
View Download 0.471 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.479 a.4.1 Homeodomain-like
View Download 0.457 a.4.5 "Winged helix" DNA-binding domain
View Download 0.453 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.448 a.60.2 RuvA domain 2-like
View Download 0.426 a.74.1 Cyclin-like
View Download 0.383 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.371 a.3.1 Cytochrome c
View Download 0.355 a.50.1 Anaphylotoxins (complement system)
View Download 0.350 a.64.2 Bacteriocin AS-48
View Download 0.305 a.6.1 Putative DNA-binding domain
View Download 0.274 a.20.1 PGBD-like
View Download 0.269 a.60.1 SAM/Pointed domain
View Download 0.260 a.17.1 p8-MTCP1
View Download 0.254 a.4.1 Homeodomain-like
View Download 0.252 a.64.1 Saposin
View Download 0.225 a.4.5 "Winged helix" DNA-binding domain
View Download 0.215 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.215 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.213 a.4.5 "Winged helix" DNA-binding domain
View Download 0.203 a.140.2 SAP domain

Predicted Domain #2
Region A:
Residues: [66-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDCKIKIAHG TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA  60
   61 DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQY KGAGLSMGTM ICGYTRKEGP 120
  121 TIYYVDSDGT RLKGDIFCVG SGQTFAYGVL DSNYKWDLSV EDALYLGKRS ILAAAHRDAY 180
  181 SGGSVNLYHV TEDGWIYHGN HDVGELFWKV KEEEGSFNNV IG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1302.69897
Match: 1g0uK_
Description: Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle