YRC Public Data Repository - Protein Structure Prediction

Protein:	DIB1
Organism:	Saccharomyces cerevisiae
Length:	143 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DIB1.

Description	E-value	Query Range	Subject Range
TXN4A_MOUSE - Thioredoxin-like protein 4A OS=Mus musculus GN=Txnl4a PE=1 SV=1 TXNL4A - thioredoxin-like 4A gi\|149015925, gi... - ref\|XP_214528.1\| similar to dim1 [Rattus norvegicus], gi\|149015925\|gb\|EDL75232.1\| similar to DNA se... gi\|55250488 - gb\|AAH86032.1\| Unknown (protein for MGC:98130) [Xenopus laevis] CCDS32852.1_1 - null ENSCJAT00000019678 - null gi\|109122568 - gi\|109122568\|ref\|XP_001089626.1\| PREDICTED: thioredoxin-like 4A [Macaca mulatta]	4.0E-41	[3..140]	[2..139]
Dim1-PA - The gene Dim1 is referred to in FlyBase by the symbol Dmel\Dim1 (CG3058, FBgn0031601). It is a prote... gi\|54645310, gi\|... - gi\|54645310\|gb\|EAL34050.1\| GA15896 [Drosophila pseudoobscura pseudoobscura], gi\|125986441\|ref\|XP_001... gi\|195471256, gi... - gi\|195471256\|ref\|XP_002087921.1\| GE18287 [Drosophila yakuba], gi\|194174022\|gb\|EDW87633.1\| GE18287 [D... gi\|194162906, gi... - gi\|195437787\|ref\|XP_002066821.1\| GK24348 [Drosophila willistoni], gi\|194162906\|gb\|EDW77807.1\| GK2434... gi\|220947888, gi... - gi\|220957200\|gb\|ACL91143.1\| Dim1-PA [synthetic construct], gi\|220947888\|gb\|ACL86487.1\| Dim1-PA [synt... gi\|125986441\|ref... - GA15896-PA [Drosophila pseudoobscura], GA15896 [Drosophila pseudoobscura pseudoobscura] gi\|194766239, gi... - gi\|194766239\|ref\|XP_001965232.1\| GF21189 [Drosophila ananassae], gi\|190617842\|gb\|EDV33366.1\| GF21189... gi\|195035719, gi... - gi\|195035719\|ref\|XP_001989319.1\| GH10125 [Drosophila grimshawi], gi\|193905319\|gb\|EDW04186.1\| GH10125... gi\|190660535, gi... - gi\|194856066\|ref\|XP_001968668.1\| GG25001 [Drosophila erecta], gi\|190660535\|gb\|EDV57727.1\| GG25001 [D... gi\|195159534, gi... - gi\|195159534\|ref\|XP_002020633.1\| GL15133 [Drosophila persimilis], gi\|194117583\|gb\|EDW39626.1\| GL1513... gi\|195118000, gi... - gi\|195118000\|ref\|XP_002003528.1\| GI22095 [Drosophila mojavensis], gi\|193914103\|gb\|EDW12970.1\| GI2209... gi\|194149220, gi... - gi\|195388184\|ref\|XP_002052763.1\| GJ19964 [Drosophila virilis], gi\|194149220\|gb\|EDW64918.1\| GJ19964 [... gi\|195342451, gi... - gi\|195342451\|ref\|XP_002037814.1\| GM18471 [Drosophila sechellia], gi\|194132664\|gb\|EDW54232.1\| GM18471...	6.0E-41	[3..140]	[2..139]
gi\|21300089, gi\|... - gi\|31222366\|ref\|XP_317168.1\| AGAP008298-PA [Anopheles gambiae str. PEST], gi\|21300089\|gb\|EAA12234.1\|... AGAP008298-PA - U5 snRNP protein, DIM1 family\|protein_coding\|3R:8640494:8641029:1\|gene:AGAP008298	1.0E-40	[3..140]	[2..139]
YLS8_ARATH - Thioredoxin-like protein YLS8 OS=Arabidopsis thaliana GN=YLS8 PE=2 SV=1	2.0E-40	[3..140]	[2..139]
gi\|226498606, gi... - gi\|226498606\|ref\|NP_001148867.1\| mitosis protein dim1 [Zea mays], gi\|195622740\|gb\|ACG33200.1\| mitosi... gi\|218199272 - gi\|218199272\|gb\|EEC81699.1\| hypothetical protein OsI_25296 [Oryza sativa Indica Group] gi\|242079123, gi... - gi\|242092472\|ref\|XP_002436726.1\| hypothetical protein SORBIDRAFT_10g007680 [Sorghum bicolor], gi\|242... gi\|31432762, gi\|... - gi\|50935019\|ref\|XP_477037.1\| putative dim1p [Oryza sativa (japonica cultivar-group)], gi\|50508616\|db... gi\|18087886\|gb\|A... - putative thioredoxin-like U5 small ribonucleoprotein particle protein [Oryza sativa]	8.0E-40	[3..140]	[2..139]
dim1 - U4 /U6 x U5 tri-snRNP complex subunit Dim1 DIMI_SCHPO - Mitosis protein dim1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dim1 PE=1 SV=1	1.0E-37	[3..140]	[2..139]
gi\|23484436 - gi\|23484436\|gb\|EAA19764.1\| Drosophila melanogaster RE13747p [Plasmodium yoelii yoelii] gi\|82793842 - gi\|82793842\|ref\|XP_728199.1\| hypothetical protein [Plasmodium yoelii yoelii str. 17XNL]	2.0E-37	[3..140]	[2..139]
gi\|32493106 - gi\|32493106\|gb\|AAP85544.1\| putative DIM-like protein [Glycine max]	6.0E-37	[9..140]	[3..134]
DIB1 - 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue... DIB1_YEAST - Spliceosomal protein DIB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DIB1 PE=1 SV=1	9.0E-37	[1..143]	[1..143]

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Predicted Domain #1

Region A:
Residues: [1-143]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVLLPQLR TGWHVDQAIV TETKRLVVIR FGRKNDRQCM IMDELLSSIA ERVRNFAVIY  60
   61 LCDIDEVSDF DEMYELTDPM TVMFFYHNKH MMCDFGTGNN NKLNFIVDDK QEMIDILETI 120
  121 FRGARKNKGL VVSPYDYNHK RVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	516.927757
Match:	1qgvA_
Description:	spliceosomal protein U5-15Kd
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
	5.14545280785816	bayes_pls_golite062009
binding	1.25802922431343	bayes_pls_golite062009
transcription regulator activity	1.20376609684075	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
protein binding	0.134341907247724	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: