YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: PCL8
Organism: Saccharomyces cerevisiae
Length: 492 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCL8.

Description E-value Query
Range
Subject
Range
gi|207340720 - gi|207340720|gb|EDZ68981.1| YPL219Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407744 - gi|190407744|gb|EDV11009.1| cyclin [Saccharomyces cerevisiae RM11-1a]
PCL8_YEAST - PHO85 cyclin-8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL8 PE=1 SV=1
PCL8 - Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen s...
0.0 [1..492] [1..492]
CCNY_MOUSE - Cyclin-Y OS=Mus musculus GN=Ccny PE=1 SV=1
6.0E-61 [218..492] [3..288]
HGNC:23354|MIM:6... - Y
CCNY - cyclin Y
gi|109088721 - gi|109088721|ref|XP_001094187.1| PREDICTED: similar to cyclin fold protein 1 isoform 1 isoform 7 [Ma...
gi|208967727, gi... - gi|208967727|dbj|BAG72509.1| cyclin Y [synthetic construct], gi|117644480|emb|CAL37735.1| hypothetic...
5.0E-60 [218..492] [3..288]
gi|12005319 - gi|12005319|gb|AAG44390.1| cyclin 4 [Trypanosoma cruzi]
5.0E-59 [119..486] [64..444]

Back

Predicted Domain #1
Region A:
Residues: [1-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANDQDPNKS LINDALTRSM SEFYDDDDDN DSDMCRANDE GEDVFDLPLK VGVSQSRNFS  60
   61 EVNDVLDPLS SLHGPSKKVR FEQQKQQQQH QQLHNDFNTD FNLKSPSSKK MGVEQLIQSA 120
  121 NEINDYLANN IDKVNSFNSE LLSGSGKLPG RVKSDTATQG TGRLDSMSNF ALSDTELDND 180
  181 DDNYLLDPLA NASSTTPTVE HHGYSLLDKA LSTSDKEKIY TNKVNSNSQI DTDNHSHESG 240
  241 NTTNNETDEN ESSEILDYTK FDSFPYPPSS APNGEPPDLK VLSIECEQEN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [291-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKELRRISLL LDHYESIPKI PELSDDEALS KFRENIELIL QLSKKINDNA NTLAISSEDP  60
   61 QKFVNFVMKN PPSLSFRDFI DRIQNKCMFG AVVYLGATYL LQLVFLTRDE MDGPIKLKAK 120
  121 LQEDQAHRII ISTIRIATKL LEDFVHSQNY ICKVFGISKR LLTKLEISFM ASVNFDGLMI 180
  181 TCEKLEKTLH ILDDTRQALG NT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [309-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIPELSDDEA LSKFRENIEL ILQLSKKIND NANTLAISSE DPQKFVNFVM KNPPSLSFRD  60
   61 FIDRIQNKCM FGAVVYLGAT YLLQLVFLTR DEMDGPIKLK AKLQEDQAHR IIISTIRIAT 120
  121 KLLEDFVHSQ NYICKVFGIS KRLLTKLEIS FMASVNFDGL MITCEKLEKT LHILDDTRQA 180
  181 LGNT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.39
Match: 1f5qB
Description: Viral cyclin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 5.12463430024071 bayes_pls_golite062009
cyclin-dependent protein kinase activity 1.93343502830716 bayes_pls_golite062009
binding 1.73927974260891 bayes_pls_golite062009
protein binding 1.37207701115974 bayes_pls_golite062009
transcription regulator activity 1.31222872955439 bayes_pls_golite062009
nucleic acid binding 0.802637318318368 bayes_pls_golite062009
kinase regulator activity 0.753288291901404 bayes_pls_golite062009
protein kinase regulator activity 0.713321295552366 bayes_pls_golite062009
DNA binding 0.660292655137288 bayes_pls_golite062009
enzyme regulator activity 0.461517963237846 bayes_pls_golite062009
transcription repressor activity 0.290993164406505 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.181080585275576 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle