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View Structure Prediction Details

Protein: TYW1
Organism: Saccharomyces cerevisiae
Length: 810 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYW1.

Description E-value Query
Range
Subject
Range
TYW1_YEAST - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Saccharomyces cerevisiae (strai...
gi|151942594 - gi|151942594|gb|EDN60940.1| tRNA-YW synthesizing protein [Saccharomyces cerevisiae YJM789]
TYW1 - Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adja...
gi|190407756 - gi|190407756|gb|EDV11021.1| hypothetical protein SCRG_02292 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..810] [1..810]
TYW1_MOUSE - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Mus musculus GN=Tyw1 PE=1 SV=1
0.0 [139..790] [9..716]
TYW1_SCHPO - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Schizosaccharomyces pombe (stra...
SPCC1020.08 - wybutosine biosynthesis protein Tyw1
0.0 [126..803] [13..680]
gi|33991532 - gi|33991532|gb|AAH15591.1| TYW1 protein [Homo sapiens]
0.0 [138..733] [10..662]
TYW1_ARATH - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Arabidopsis thaliana GN=TYW1 PE...
0.0 [199..795] [44..643]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [199..795] [44..650]
gi|85104851 - gi|85104851|ref|XP_961821.1| hypothetical protein NCU06633 [Neurospora crassa OR74A]
gi|28923398, gi|... - gi|32412015|ref|XP_326488.1| hypothetical protein [Neurospora crassa], gi|28923398|gb|EAA32585.1| hy...
0.0 [145..788] [352..1056]
TYW1_ORYSJ - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Oryza sativa subsp. japonica GN...
gi|125545879 - gi|125545879|gb|EAY92018.1| hypothetical protein OsI_13711 [Oryza sativa Indica Group]
0.0 [206..790] [57..646]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGFRVAGAL VVGALTAAYL YFGGRFSIAL VIIVGYGIYC NEASGGSQDS QEKLDLNKQQ  60
   61 KKPCCSDKKI ADGGKKTGGC CSDKKNGGGK GGGCCSSKGG KKGGCCSSKG GKKGGCCSSK 120
  121 KNI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [124-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDNENTATEV EKAVNYPVTV DFTEVFRKPT KKRSSTPKVF SKNSSSNSRV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 4nosA_
Description: Nitric oxide (NO) synthase oxygenase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [174-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKKLSVSKKI GPDGLIKSAL TISNETLLSS QIYVLYSSLQ GAASKAAKSV YDKLKELDEL  60
   61 TNEPKLLNLD DLSDFDDYFI NVPVENALYV LVLPSYDIDC PLDYFLQTLE ENANDFRVDS 120
  121 FPLRKLVGYT VLGLGDSESW PEKFCYQAKR ADHWISRLGG RRIFPLGKVC MKTGGSAKID 180
  181 EWTSLLAETL KDDEPIIYEY DENADSEEDE EEGNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.39794
Match: 1j9zA_
Description: NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 0.62629924591908 bayes_pls_golite062009
binding 0.523120840489436 bayes_pls_golite062009
catalytic activity 0.275631658558537 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [389-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDELGDVEDI GGKGSNGKFS GADEIKQMVA KDSPTYKNLT KQGYKVIGSH SGVKICR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.39794
Match: 1j9zA_
Description: NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.48331922124015 bayes_pls_golite062009
transferase activity 0.685192555939835 bayes_pls_golite062009
binding 0.60397276396442 bayes_pls_golite062009
protein binding 0.124485878765261 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [446-728]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WTKNELRGKG SCYKKSLFNI ASSRCMELTP SLACSSKCVF CWRHGTNPVS KNWRWEVDEP  60
   61 EYILENALKG HYSMIKQMRG VPGVIAERFA KAFEVRHCAL SLVGEPILYP HINKFIQLLH 120
  121 QKGITSFLVC NAQHPEALRN IVKVTQLYVS IDAPTKTELK KVDRPLYKDF WERMVECLEI 180
  181 LKTVQNHQRT VFRLTLVKGF NMGDVSAYAD LVQRGLPGFI EVKGATFSGS SDGNGNPLTM 240
  241 QNIPFYEECV KFVKAFTTEL QRRGLHYDLA AEHAHSNCLL IAD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [729-810]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKFKINGEWH THIDFDKFFV LLNSGKDFTY MDYLEKTPEW ALFGNGGFAP GNTRVYRKDK  60
   61 KKQNKENQET TTRETPLPPI PA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle