YRC Public Data Repository - Protein Structure Prediction

Protein:	PPQ1
Organism:	Saccharomyces cerevisiae
Length:	549 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPQ1.

Description	E-value	Query Range	Subject Range
gi\|207340671 - gi\|207340671\|gb\|EDZ68952.1\| YPL179Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151942620 - gi\|151942620\|gb\|EDN60966.1\| protein phosphatase Q [Saccharomyces cerevisiae YJM789] PPQ1_YEAST - Serine/threonine-protein phosphatase PPQ OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... PPQ1 - Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational su...	0.0	[1..535]	[1..535]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[233..541]	[1..303]
PP1GB_XENLA - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B OS=Xenopus laevis GN=ppp1cc-b PE=...	0.0	[234..549]	[3..310]
gi\|114646944, gi... - gi\|114646944\|ref\|XP_001144540.1\| PREDICTED: protein phosphatase 1, catalytic subunit, gamma isoform ... gi\|109098734 - gi\|109098734\|ref\|XP_001108424.1\| PREDICTED: similar to protein phosphatase 1, catalytic subunit, gam... gi\|67971066 - gi\|67971066\|dbj\|BAE01875.1\| unnamed protein product [Macaca fascicularis] gi\|61363508, gi\|... - gi\|61363508\|gb\|AAX42403.1\| protein phosphatase 1 catalytic subunit gamma isoform [synthetic construc... PPP1CC - protein phosphatase 1, catalytic subunit, gamma isozyme	0.0	[236..549]	[5..310]
gi\|1280039, gi\|1... - gi\|1945547\|dbj\|BAA19729.1\| PP1gamma [Mus musculus], gi\|1280039\|gb\|AAC53383.1\| protein phosphatase 1c...	0.0	[236..549]	[5..310]
PP1G_RAT - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Rattus norvegicus GN=Ppp1cc PE=1... gi\|55250791 - gb\|AAH86013.1\| Unknown (protein for MGC:98061) [Xenopus laevis] PP1G_BOVIN - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Bos taurus GN=PPP1CC PE=2 SV=1 PP1G_MOUSE - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Mus musculus GN=Ppp1cc PE=1 SV=1 gi\|87621736, gi\|... - gi\|87621736\|gb\|ABD38709.1\| protein phosphatase 1 catalytic subunit gamma isoform [Sus scrofa], gi\|11...	0.0	[236..549]	[5..310]
PP1G_CANLF - Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Canis lupus familiaris GN=PPP1CC...	0.0	[236..549]	[5..310]

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Predicted Domain #1

Region A:
Residues: [1-72]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRSPSRSNN NFAVPNCSTN SNSSQQQLTT PSDDLNSNEP NDPDDSRSLP TIKKFNNKHS  60
   61 INNYNTLASA GK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.22791066554607	bayes_pls_golite062009
phosphatase activity	6.21754026490199	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.00674602220619	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.86006406811342	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.18314342778634	bayes_pls_golite062009
binding	2.71974493738804	bayes_pls_golite062009
protein binding	2.67835748923436	bayes_pls_golite062009
transcription regulator activity	2.36571535004008	bayes_pls_golite062009
DNA binding	1.71381351716702	bayes_pls_golite062009
nucleic acid binding	1.62783430593918	bayes_pls_golite062009
transcription factor activity	1.01338808398786	bayes_pls_golite062009
oxidoreductase activity	0.967526235944614	bayes_pls_golite062009
acetylglucosaminyltransferase activity	0.78476205818302	bayes_pls_golite062009
receptor activity	0.765633559982614	bayes_pls_golite062009
molecular transducer activity	0.679771252160931	bayes_pls_golite062009
signal transducer activity	0.679771252160931	bayes_pls_golite062009
hydrolase activity	0.619711232527193	bayes_pls_golite062009
N-acetyltransferase activity	0.606264963283666	bayes_pls_golite062009
transcription factor binding	0.518146612491969	bayes_pls_golite062009
RNA binding	0.497066934302855	bayes_pls_golite062009
signal sequence binding	0.49295886046194	bayes_pls_golite062009
N-acyltransferase activity	0.370858685623455	bayes_pls_golite062009
transcription cofactor activity	0.30464889749774	bayes_pls_golite062009
peptide binding	0.280393897104229	bayes_pls_golite062009
transferase activity	0.127854220687373	bayes_pls_golite062009
transcription coactivator activity	0.116119418380222	bayes_pls_golite062009
ligase activity	0.102007806594868	bayes_pls_golite062009
transcription activator activity	0.0593768116971065	bayes_pls_golite062009
acetyltransferase activity	0.0233291331884218	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [73-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNKRASND NLLIPGENAH KQKIYTKDEN LKSLYLDIDV SVAKALSSSA TAPKLINTAR  60
   61 TSSTTTATTS NNILTSPSYR ESNYSSPSSY SFSSYYSSAT SASSSTSSFL KSSGLSSRVK 120
  121 SPSSSVKAGS FGAPSSPTSG IPNPKSSKKP IFLRRYSHD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.39794
Match:	1a17__
Description:	Protein phosphatase 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
kinase activity	0.671153901928902	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.653838048261886	bayes_pls_golite062009
molecular transducer activity	0.632790145692488	bayes_pls_golite062009
signal transducer activity	0.632790145692488	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.574603802558181	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
protein kinase activity	0.375779843321939	bayes_pls_golite062009
transferase activity	0.319184977255763	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [232-549]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSNEGLDID VAIEKLLQVG ESREITKTSK KKNFPFHSWE IQLICYHARE IFLNQPTLLR  60
   61 LQAPIKVVGD VHGQFNDLLR ILKLSGVPSD TNYLFLGDYV DRGKNSLETI LLLLCYKIKY 120
  121 KDNFFMLRGN HESANVTKMY GFYDECKRRL SSKVWKMFVD VFNTLPLAAI IQDKIFCVHG 180
  181 GISPDLHDMK QIEKVARPTD IPESGLVTDL LWSDPDPQVT DWSENDRGVS YTFSKRNVLD 240
  241 FCAKFKFDLI LRGHMVVEDG YEFFARKKFV TIFSAPNYCG EFHNWGAVMS VTTGMMCSFE 300
  301 LLKPRALKNK KKLYKTKV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1302.0
Match:	1fjmA_
Description:	Protein phosphatase-1 (PP-1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: