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View Structure Prediction Details

Protein: HHO1
Organism: Saccharomyces cerevisiae
Length: 258 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HHO1.

Description E-value Query
Range
Subject
Range
gi|32480770 - gi|32480770|gb|AAO26655.1| SNF2 histone linker PHD RING helicase isoform B [Mus musculus]
2.0E-24 [38..199] [163..319]
gi|190407831 - gi|190407831|gb|EDV11096.1| histone H1 [Saccharomyces cerevisiae RM11-1a]
HHO1 - Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA r...
H1_YEAST - Histone H1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HHO1 PE=1 SV=1
2.0E-23 [1..258] [1..258]
gi|27436873, gi|... - gi|27436873|ref|NP_775105.1| SNF2 histone linker PHD RING helicase isoform b [Homo sapiens], gi|2736...
9.0E-23 [38..164] [433..556]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPKKSTTKT TSKGKKPATS KGKEKSTSKA AIKKTTAKKE EASSKSYREL IIEGLTALKE  60
   61 RKGSSRPALK KFIKENYPIV GSASNFDLYF NNAIKKGVEA GDFEQPKGPA GAVKLAKKKS 120
  121 PEVKKEKEVS PKPKQAATSV SA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1hstA_
Description: Histone H5, globular domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [143-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TASKAKAAST KLAPKKVVKK KSPTVTAKKA SSPSSLTYKE MILKSMPQLN DGKGSSRIVL  60
   61 KKYVKDTFSS KLKTSSNFDY LFNSAIKKCV ENGELVQPKG PSGIIKLNKK KVKLST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.564 0.482 nuclear nucleosome a.1.1 Globin-like
View Download 0.661 0.080 nuclear nucleosome a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.552 0.020 nuclear nucleosome a.4.3 ARID-like
View Download 0.486 N/A N/A a.22.1 Histone-fold
View Download 0.452 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.429 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.404 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.386 N/A N/A a.4.1 Homeodomain-like
View Download 0.385 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.370 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.345 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.340 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.333 N/A N/A a.4.3 ARID-like
View Download 0.332 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.316 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.307 N/A N/A a.1.1 Globin-like
View Download 0.300 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.290 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.281 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.277 N/A N/A a.1.1 Globin-like
View Download 0.267 N/A N/A a.3.1 Cytochrome c
View Download 0.264 N/A N/A a.1.1 Globin-like
View Download 0.261 N/A N/A a.118.8 TPR-like
View Download 0.253 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.253 N/A N/A d.110.4 SNARE-like
View Download 0.251 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.250 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.246 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.244 N/A N/A a.1.1 Globin-like
View Download 0.243 N/A N/A a.74.1 Cyclin-like
View Download 0.234 N/A N/A a.4.1 Homeodomain-like
View Download 0.225 N/A N/A a.1.1 Globin-like
View Download 0.216 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.213 N/A N/A a.1.1 Globin-like
View Download 0.212 N/A N/A a.39.1 EF-hand
View Download 0.210 N/A N/A a.46.1 Methionine synthase domain
View Download 0.205 N/A N/A a.4.12 TrpR-like
View Download 0.203 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

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