YRC Public Data Repository - Protein Structure Prediction

Protein:	MSY1
Organism:	Saccharomyces cerevisiae
Length:	492 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSY1.

Description	E-value	Query Range	Subject Range
SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis (strain SC-B67) GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=tyrS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=tyrS] [protein=tyrosyl-tRNA synthetase] [protein_id=YP_005237319.1] [location=1533463..1534737... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosine--tRNA ligase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALCH - Tyrosyl-tRNA synthetase OS=Salmonella choleraesuis GN=tyrS PE=3 SV=1 SYY_SALPA - Tyrosine--tRNA ligase OS=Salmonella paratyphi A GN=tyrS PE=3 SV=1 SYY_SALTY - Tyrosyl-tRNA synthetase OS=Salmonella typhimurium GN=tyrS PE=3 SV=1 SYY_SALTI - Tyrosyl-tRNA synthetase OS=Salmonella typhi GN=tyrS PE=3 SV=1 SYY_SALSV - Tyrosine--tRNA ligase OS=Salmonella schwarzengrund (strain CVM19633) GN=tyrS PE=3 SV=1 SYY_SALA4 - Tyrosine--tRNA ligase OS=Salmonella agona (strain SL483) GN=tyrS PE=3 SV=1 gi\|197239883, gi... - gi\|197261628\|ref\|ZP_03161702.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALPK - Tyrosine--tRNA ligase OS=Salmonella paratyphi A (strain AKU_12601) GN=tyrS PE=3 SV=1 gi\|168819199, gi... - gi\|205343665\|gb\|EDZ30429.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Wel... SYY_SALNS - Tyrosine--tRNA ligase OS=Salmonella newport (strain SL254) GN=tyrS PE=3 SV=1 SYY_SALHS - Tyrosine--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=tyrS PE=3 SV=1 gi\|194469349, gi... - gi\|194469349\|ref\|ZP_03075333.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|238913150 - gi\|238913150\|ref\|ZP_04656987.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|167994279, gi... - gi\|205327841\|gb\|EDZ14605.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,[... gi\|168229823, gi... - gi\|205335458\|gb\|EDZ22222.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ken... gi\|168235521, gi... - gi\|197291166\|gb\|EDY30519.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sch... SYY_SALPB - Tyrosine--tRNA ligase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|168463140, gi... - gi\|195634532\|gb\|EDX52884.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar New... SYY_SALPB - Tyrosyl-tRNA synthetase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=tyrS PE=3 SV=1 gi\|205323596, gi... - gi\|205323596\|gb\|EDZ11435.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Sai... SYY_SALTY - Tyrosine--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tyrS PE=3 S... gi\|214000281 - gi\|214000281\|ref\|ZP_03411016.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|29141776, gi\|... - gi\|29141776\|ref\|NP_805118.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... SYY_SALTI - Tyrosine--tRNA ligase OS=Salmonella typhi GN=tyrS PE=3 SV=1 gi\|213425988 - gi\|213425988\|ref\|ZP_03358738.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213622227 - gi\|213622227\|ref\|ZP_03375010.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|16760464 - gi\|16760464\|ref\|NP_456081.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Ty... gi\|213649176 - gi\|213649176\|ref\|ZP_03379229.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... gi\|213857492 - gi\|213857492\|ref\|ZP_03384463.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALDC - Tyrosine--tRNA ligase OS=Salmonella dublin (strain CT_02021853) GN=tyrS PE=3 SV=1 gi\|204927912, gi... - gi\|204927912\|ref\|ZP_03219113.1\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar... SYY_SALG2 - Tyrosine--tRNA ligase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=tyrS PE=3 SV=1 gi\|205358968, gi... - gi\|205358968\|ref\|ZP_02665896.2\| tyrosyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar...	0.0	[53..492]	[3..424]
SYY_ECOLI - (P0AGJ9) Tyrosyl-tRNA synthetase (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS) SYY_ECO57 - (P0AGK0) Tyrosyl-tRNA synthetase (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS) SYY_SHISS - (Q3Z1Z3) Tyrosyl-tRNA synthetase (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS)	0.0	[53..492]	[2..423]
SYY_ECOBW - Tyrosine--tRNA ligase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=tyrS PE=3 SV=1 gi\|254793254, gi... - gi\|254793254\|ref\|YP_003078091.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14359], gi... gi\|217318164, gi... - gi\|217328817\|ref\|ZP_03444898.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14588], gi\|... SYY_ECO7I - Tyrosine--tRNA ligase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=tyrS PE=3 SV=1 SYY_ECOLU - Tyrosine--tRNA ligase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=tyrS PE=3 SV=1 EG11043 - tyrosyl-tRNA synthetase / Tyrosine--tRNA ligase gi\|89108479, gi\|... - gi\|89108479\|ref\|AP_002259.1\| tyrosyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], gi\|... SYY_ECOHS - Tyrosine--tRNA ligase OS=Escherichia coli O9:H4 (strain HS) GN=tyrS PE=3 SV=1 SYY_ECO24 - Tyrosine--tRNA ligase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=tyrS PE=3 SV=1 SYY_SHISS - Tyrosine--tRNA ligase OS=Shigella sonnei (strain Ss046) GN=tyrS PE=3 SV=3 SYY_ECO57 - Tyrosine--tRNA ligase OS=Escherichia coli O157:H7 GN=tyrS PE=3 SV=2 EG11043 - tyrosyl-tRNA synthetase / Tyrosine--tRNA ligase SYY_ECOLI - Tyrosyl-tRNA synthetase (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS) - Escherichia coli SYY_ECOLC - Tyrosine--tRNA ligase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=tyrS PE=3 SV=1 gi\|15831600, gi\|... - gi\|15831600\|ref\|NP_310373.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|13361... gi\|124529206, gi... - gi\|124529206\|ref\|ZP_01700281.1\| tyrosyl-tRNA synthetase [Escherichia coli B], gi\|124499980\|gb\|EAY474... gi\|208816760, gi... - gi\|208816760\|ref\|ZP_03257880.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4045], gi\|2... gi\|208821747, gi... - gi\|208821747\|ref\|ZP_03262067.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4042], gi\|2... SYY_ECO5E - Tyrosine--tRNA ligase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=tyrS PE=3 SV=1 SYY_ECOSE - Tyrosine--tRNA ligase OS=Escherichia coli (strain SE11) GN=tyrS PE=3 SV=1 gi\|188495334, gi... - gi\|188495334\|ref\|ZP_03002604.1\| tyrosyl-tRNA synthetase [Escherichia coli 53638], gi\|188490533\|gb\|ED... gi\|191173441, gi... - gi\|191173441\|ref\|ZP_03034969.1\| tyrosyl-tRNA synthetase [Escherichia coli F11], gi\|190906283\|gb\|EDV6... gi\|192956440, gi... - gi\|193070259\|ref\|ZP_03051203.1\| tyrosyl-tRNA synthetase [Escherichia coli E110019], gi\|192956440\|gb\|... gi\|208810466, gi... - gi\|208810466\|ref\|ZP_03252342.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4206], gi\|2... gi\|189370947, gi... - gi\|189370947\|gb\|EDU89363.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC869], gi\|168789... SYY_ECODH - Tyrosine--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=tyrS PE=3 SV=1 SYY_ECOSM - Tyrosine--tRNA ligase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=tyrS PE=3 SV=1 SYY_SHIB3 - Tyrosine--tRNA ligase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=tyrS PE=3 SV=1 gi\|168775869, gi... - gi\|187768721\|gb\|EDU32565.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4196], gi\|16877... gi\|188999202, gi... - gi\|188999202\|gb\|EDU68188.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4076], gi\|16878...	0.0	[53..492]	[3..424]
gi\|75234950 - gi\|75234950\|ref\|ZP_00719229.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli E110019] gi\|75195717 - gi\|75195717\|ref\|ZP_00705787.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli HS] gi\|75190677 - gi\|75190677\|ref\|ZP_00703944.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli E24377A] gi\|75178466 - gi\|75178466\|ref\|ZP_00698512.1\| COG0162: Tyrosyl-tRNA synthetase [Shigella boydii BS512] gi\|25292889, gi\|... - gi\|25292889\|pir\|\|F85770 tyrosine tRNA synthetase [imported] - Escherichia coli (strain O157:H7, sub... gi\|75512930 - gi\|75512930\|ref\|ZP_00735411.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli 53638] gi\|15802051, gi\|... - gi\|15802051\|ref\|NP_288073.1\| tyrosyl-tRNA synthetase [Escherichia coli O157:H7 EDL933], gi\|12515629\|... gi\|75238802 - gi\|75238802\|ref\|ZP_00722786.1\| COG0162: Tyrosyl-tRNA synthetase [Escherichia coli F11]	0.0	[53..492]	[7..428]
gi\|30063152, gi\|... - gi\|30063152\|ref\|NP_837323.1\| tyrosyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|30041401\|... gi\|194417461, gi... - gi\|194434313\|ref\|ZP_03066578.1\| tyrosyl-tRNA synthetase [Shigella dysenteriae 1012], gi\|194417461\|gb...	0.0	[53..492]	[3..424]
SYY_ECOK1 - Tyrosine--tRNA ligase OS=Escherichia coli O1:K1 / APEC GN=tyrS PE=3 SV=1 SYY_ECOUT - Tyrosine--tRNA ligase OS=Escherichia coli (strain UTI89 / UPEC) GN=tyrS PE=3 SV=1 gi\|227885946, gi... - gi\|227885946\|ref\|ZP_04003751.1\| tyrosyl-tRNA synthetase [Escherichia coli 83972], gi\|227837125\|gb\|EE... gi\|26247884, gi\|... - gi\|26247884\|ref\|NP_753924.1\| tyrosyl-tRNA synthetase [Escherichia coli CFT073], gi\|26108287\|gb\|AAN80...	0.0	[53..492]	[7..428]
SYY_GEOSE - Tyrosine--tRNA ligase OS=Geobacillus stearothermophilus GN=tyrS PE=1 SV=1	0.0	[54..491]	[1..418]
SYY_BACCA - Tyrosine--tRNA ligase OS=Bacillus caldotenax GN=tyrS PE=3 SV=1	0.0	[54..491]	[1..418]
gi\|229694257, gi... - gi\|229837891\|ref\|ZP_04458050.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. PEXU... gi\|229895051, gi... - gi\|229895051\|ref\|ZP_04510228.1\| tyrosyl-tRNA synthetase [Yersinia pestis Pestoides A], gi\|229701939\|... SYY_YERPG - Tyrosine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=tyrS PE=3 SV=1 gi\|218929460, gi... - gi\|218929460\|ref\|YP_002347335.1\| tyrosyl-tRNA synthetase [Yersinia pestis CO92], gi\|16122592\|ref\|NP_... SYY_YERPE - Tyrosine--tRNA ligase OS=Yersinia pestis GN=tyrS PE=3 SV=1 gi\|149292133, gi... - gi\|149365720\|ref\|ZP_01887755.1\| tyrosyl-tRNA synthetase [Yersinia pestis CA88-4125], gi\|149292133\|gb... SYY_YERPP - Tyrosine--tRNA ligase OS=Yersinia pestis (strain Pestoides F) GN=tyrS PE=3 SV=1 gi\|229688498, gi... - gi\|229898454\|ref\|ZP_04513600.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. Indi... gi\|167400938, gi... - gi\|167400938\|ref\|ZP_02306444.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. UG05-04... gi\|167422142, gi... - gi\|167422142\|ref\|ZP_02313895.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. MG05... gi\|167424859, gi... - gi\|167424859\|ref\|ZP_02316612.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Mediaevalis str. K19... gi\|165921638, gi... - gi\|165926417\|ref\|ZP_02222249.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. F199... gi\|165938656, gi... - gi\|165938656\|ref\|ZP_02227212.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. IP27... SYY_YERPA - Tyrosine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=tyrS PE=3 SV=1 gi\|165990404, gi... - gi\|166010702\|ref\|ZP_02231600.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. E197900... SYY_YERPN - Tyrosine--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=tyrS PE=3 SV=1 gi\|166208225, gi... - gi\|166211045\|ref\|ZP_02237080.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. B420030...	0.0	[53..491]	[3..423]
gi\|77633734 - gi\|77633734\|ref\|ZP_00795853.1\| COG0162: Tyrosyl-tRNA synthetase [Yersinia pestis Angola] gi\|22125858, gi\|... - gi\|22125858\|ref\|NP_669281.1\| tyrosyl-tRNA synthetase [Yersinia pestis KIM], gi\|21958790\|gb\|AAM85532.... gi\|45441947, gi\|... - gi\|45441947\|ref\|NP_993486.1\| tyrosyl-tRNA synthetase [Yersinia pestis biovar Microtus str. 91001], g... gi\|89103782 - gi\|89103782\|ref\|ZP_01176346.1\| COG0162: Tyrosyl-tRNA synthetase [Yersinia pestis biovar Orientalis s...	0.0	[53..491]	[7..427]

Back

Predicted Domain #1

Region A:
Residues: [1-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLELRSCSNL VNSSRRLVPL VTYSGLSAIT LPKSRFYSQP SALEVQGTSD SRSDNILDEL  60
   61 KQRGLVSQVS QPESFLRTKL NGNDKIKLYC GVDPTAQSLH LGNLVPLMVL LHFYVKGHDI 120
  121 VTVIGGATGK VGDPSGRKTE RDVMENDIRQ SNVASISQQL QRFFKNGLEY YRNRCALTED 180
  181 VPSGKYTPRN NFNWWKDIKM LDFLADFGRH IRVQSMLARD SISSRLQTKN GLGFNEFTYQ 240
  241 VLQAYDFYHL YKEENVTIQV GGNDQWGNIT AGIDLINRIQ PIKNKGLPFG ITVPLLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	870.0
Match:	1jiiA_
Description:	Tyrosyl-tRNA synthetase (TyrRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
tyrosine-tRNA ligase activity	6.18775771640881	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
methionine-tRNA ligase activity	2.56893064485672	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.625793556381714	bayes_pls_golite062009
nucleic acid binding	0.449504767632354	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009
binding	0.090743795600025	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [298-492]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TATGEKFGKS AGNAVFIDPS INTAYDVYQF FYNTLDADVP KFLKIFTFLN SSEIKKIVET  60
   61 HIKSPSLRYG QTLLAKEVTD MLYGVGSGSD SEALSNIIFG RYDGTLSAAK LVDLCKKARI 120
  121 LQYADREIDL IKLICKLVNC SVSEARRKLS QGSVYLHHSK SKVNENISNL APFLIDDRVL 180
  181 ILRIGKQKCF IIEMR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	870.0
Match:	1jiiA_
Description:	Tyrosyl-tRNA synthetase (TyrRS)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: