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View Structure Prediction Details

Protein: BRO1
Organism: Saccharomyces cerevisiae
Length: 844 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRO1.

Description E-value Query
Range
Subject
Range
BRO1_YEAST - Vacuolar-sorting protein BRO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRO1 PE=1 ...
BRO1 - Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the m...
0.0 [1..844] [1..844]
PTPN23 - protein tyrosine phosphatase, non-receptor type 23
1.0E-80 [4..797] [8..793]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-78 [12..726] [152..869]
gi|45383668, gi|... - gi|9800486|gb|AAF99314.1|AF272033_1 fast myosin heavy chain isoform 2 [Gallus gallus], gi|45383668|r...
2.0E-78 [12..726] [1141..1858]

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Predicted Domain #1
Region A:
Residues: [1-163]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPYLFDLKL KDTEKLDWKK GLSSYLKKSY GSSQWRTFYD EKATSELDHL RNNANGELAP  60
   61 SSLSEQNLKY YSFLEHLYFR LGSKGSRLKM DFTWYDAEYS SAQKGLKYTQ HTLAFEKSCT 120
  121 LFNIAVIFTQ IARENINEDY KNSIANLTKA FSCFEYLSEN FLN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 66.148742
Match: PF03097
Description: BRO1-like domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [164-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSVDLQSEN TRFLANICHA EAQELFVLKL LNDQISSKQY TLISKLSRAT CNLFQKCHDF  60
   61 MKEIDDDVAI YGEPKWKTTV TCKLHFYKSL SAYYHGLHLE EENRVGEAIA FLDFSMQQLI 120
  121 SSLPFKTW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.967 0.009 vacuolar transport a.19.1 Fertilization protein

Predicted Domain #3
Region A:
Residues: [292-384]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVEFIDFDGF KETLEKKQKE LIKDNDFIYH ESVPAVVQVD SIKALDAIKS PTWEKILEPY  60
   61 MQDVANKCDS LYRGIIPLDV YEKESIYSEE KAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.154902
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [385-752]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRKQVEETE TANLEYSSFI EFTNLPRLLS DLEKQFSDGN IFSNTDTQGQ LMRDQIQTWC  60
   61 KFIQTNEFRD IEEQMNKIVF KRKQILEILS ALPNDQKENV TKLKSSLVAA SNSDEKLFAC 120
  121 VKPHIVEINL LNDNGKIWKK FDEFNRNTPP QPSLLDIDDT KNDKILELLK QVKGHAEDLR 180
  181 TLKEERSRNL SELRDEINND DITKLLIINK GKSDVELKDL FEVELEKFEP LSTRIEATIY 240
  241 KQSSMIDDIK AKLDEIFHLS NFKDKSSGEE KFLEDRKNFF DKLQEAVKSF SIFASDLPKG 300
  301 IEFYDSLFNM SRDLAERVRV AKQTEDSTAN SPAPPLPPLD SKASVVGGPP LLPQKSAAFQ 360
  361 SLSRQGLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.30103
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [753-844]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGDQFQNLKI SAGSDLPQGP GIPPRTYEAS PYAATPTMAA PPVPPKQSQE DMYDLRRRKA  60
   61 VENEERELQE NPTSFYNRPS VFDENMYSKY SS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle