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View Structure Prediction Details

Protein: TEA1
Organism: Saccharomyces cerevisiae
Length: 759 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TEA1.

Description E-value Query
Range		 Subject
Range
gi|207340854 - gi|207340854|gb|EDZ69076.1| YOR337Wp-like protein [Saccharomyces cerevisiae AWRI1631]
TEA1_YEAST - TY1 enhancer activator OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TEA1 PE=1 SV=2
TEA1 - Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc clust...
 0.0 [1..759] [1..759]
NIT4_NEUCR - Nitrogen assimilation transcription factor nit-4 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1...
NIT4_NEUCR - Nitrogen assimilation transcription factor nit-4 OS=Neurospora crassa GN=nit-4 PE=4 SV=2
 1.0E-73 [19..726] [3..649]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
 5.0E-69 [1..726] [1..665]
gi|21913144 - gi|21913144|gb|AAK84946.1| transcriptional activator Mut3p [Pichia angusta]
gi|134147412 - gi|134147412|gb|ABO63963.1| transcriptional activator Mut3p [synthetic construct]
 1.0E-68 [14..743] [13..718]

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Predicted Domain #1
Region A:
Residues: [1-176] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAPLWPNKN EKNHTVKRAL STDMTSNILS STNASSNEEN SRSSSAANVR SGTGANTLTN  60
   61 GGSTRKRLAC TNCRNRRKKC DLGFPCGNCS RLELVCNVND EDLRKKRYTN KYVKSLESHI 120
  121 AQLETNLKNL VQKIYPDDEQ ILNRMMVGDV LSALPDSSQV SINYTDQTPS LPIPAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.38764
Match: 1pyiA_
Description: PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.01653715768897 bayes_pls_golite062009
nucleic acid binding 3.75642497789214 bayes_pls_golite062009
binding 3.44246337929443 bayes_pls_golite062009
transcription factor activity 2.84476696728644 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.03201524223606 bayes_pls_golite062009
sequence-specific DNA binding 1.79090232026007 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.75422925915374 bayes_pls_golite062009
transcription activator activity 0.915626626047549 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [177-241] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGTFIIENDK VSQPLSSFNQ QTEPSTLNSG IFNTQKQNFE ESLDDQLLLR RSLTPQGEKK  60
   61 KKPLV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.723 0.866 transcription a.35.1 lambda repressor-like DNA-binding domains

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 3.79493034946609 bayes_pls_golite062009
nucleic acid binding 3.56250755084815 bayes_pls_golite062009
binding 3.35126468847354 bayes_pls_golite062009
transcription factor activity 2.66881603244933 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.80191339934741 bayes_pls_golite062009
sequence-specific DNA binding 1.58478836662252 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.39996768920804 bayes_pls_golite062009
transcription activator activity 0.822069987038721 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [242-759] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSLYPEGPV SYKRKHPVKS DSLLPVSSLT AATDPSTFSD GITAGNSVLV NGELKKRISD  60
   61 LKTTVIVRGL NDDNPNSINN DPRILKSLSN FYKWLYPGYF IFVHRESFLY GFFNHSKNNY 120
  121 EDSSYCSVEL IYAMCAVGSR LTPDLQEYSE VYYQRSKKTL LQLVFDEQST ARITTVQALF 180
  181 CLAFYELGKG NNQLGWYFSG LAIRVGYDMG FQLDPKVWYV DDNNLQLTQS ELEIRSRIYW 240
  241 GCYIADHFIC LMLGRTSTLS VSNSTMPESD ELPEVNGTEE FRFIGRHVLQ ISLPLKNLII 300
  301 LSRLVQIFTS KIFIESEDIA RKLKYLNTFN SQVYNWRQSL PEFLQWSKTL IENDDVSTDP 360
  361 TISYFWYCYY IVRLTFNKPF IEDSQESETV VIEIIDDLKT LLDNFGKKFG NYTKGNLYQL 420
  421 YSCLLAINCL KKLKEIRSSE QDSWNAQLDF FNHIFYTQLY PAYDLPKKLQ EDTELETEQE 480
  481 NQMLNQVGNI NYTHDFSLSH EIDDLIRELF GVGTPQKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [512-759] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELPEVNGTEE FRFIGRHVLQ ISLPLKNLII LSRLVQIFTS KIFIESEDIA RKLKYLNTFN  60
   61 SQVYNWRQSL PEFLQWSKTL IENDDVSTDP TISYFWYCYY IVRLTFNKPF IEDSQESETV 120
  121 VIEIIDDLKT LLDNFGKKFG NYTKGNLYQL YSCLLAINCL KKLKEIRSSE QDSWNAQLDF 180
  181 FNHIFYTQLY PAYDLPKKLQ EDTELETEQE NQMLNQVGNI NYTHDFSLSH EIDDLIRELF 240
  241 GVGTPQKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle